Index

Who and where are we?

Research interest

Personnel

Publications

Research grants

Positions available:

Who and where are we?

Academic staff/Senior Scientists:

Prof. Victoriano Mulero

Prof. Alfonsa Garcia-Ayala

Dr. Mª Luisa Cayuela

Dr. Maria P. Sepulcre

Address:

Departamento de Biología Celular e Histologia, Facultad de Biologia.

Universidad de Murcia. 30100 Murcia. Spain.

Instituto Murciano de Investigación Biosanitaria (IMIB). 30120 Murcia, Spain.

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Research interest

Phylogeny of immunity:

 Cytokines: functional characterization of IL-1b, TNFa and IFNs.
 Pattern recognition receptors: functional characterization of TLRs
 Prostaglandins: role of prostaglandins, (PGE2, PGD2 and PGJ2) in the regulation of inflammation 
 Phagocytes: role of granulocytes and macrophages in the immune response 
 Gut immunity: functional characterization of mast cells
 Reproductive immunology: role of (xeno)estrogens in immunity

Aquaculture:

 Development of oral immunostimulants and adjuvants
 Development of oral vaccines

Biomedicine:

 Impact of inflammation in hematopoiesis and cancer
 Identification of new prognosis markers and therapeutic targets for psoriasis
 Identification and characterization of new inflammasome components.
 Extracurricular roles of TERC and TERT.
 Identification of new prognosis markers and therapeutic targets for dyskeratosis congenita.
 

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Personnel

Postdocs

Dr.Francisca Alcaraz-Perez palcaraz@um.es

 Extracurricular roles of TERC 

Dr. Isabel Cabas icabas@um.es

 Role of GPER1 and estrogens in immunity

Dr. Jesus Garcia-Castillo jesusgarciacastillo@gmail.com

 Extracurricular roles of TERC 
Dr. Diana Garcia-Moreno dianagm@um.es 
 Epigenetic regulation of inflammation in zebrafish
 Implementation of site directed mutagenesis by TALEN and CRISPR
 Identification and functional characterization of new inflammasome components

Dr. Victoria Gomez-Abellan vga4@um.es

 Role of prostaglandins in the regulation of fish immunity 
Dr. María A. Lopez-Muñoz malms@um.es 
 Identification and validation of new therapeutic targets and prognosis markers for psoriasis.

Dr. Ana B. Perez-Oliva anabpo@um.es

 Identification and functional characterization of new inflammasome components
 Implementation of proteomics techniques 
 Modelling the impact of inflammation and oxidative stress on melanoma development using the zebrafish.
 

PhD students

Joaquin Canton joaquin.canton@um.es

 Identification and validation of new therapeutic targets and prognosis markers for psoriasis.
 

Miriam Fernandez-Lajarin miriam.fernandez3@um.es

 Regulation of skin carcinoma by TERC

Elena Gomez-Abenza elena.gomez1@um.es

 Modelling the impact of inflammation on melanoma development using the zebrafish.

Fatma Hermi fatmahermi398@yahoo.fr

 Phylogenetic, molecular and functional characterization of fish prostaglandin receptors

David Hernadez-Silva davidhernandezsilva@gmail.com

 Identification of new small compounds to treat premature aging disorders

Amanda E. Lopez-Canovas amandaesperanza.lopez@um.es

 Slaughter stress in seabream muscle quality

Elena Martinez-Balsalobre elena.martinez20@um.es

 Regulation of hematopoiesis by TERC

Francisco J. Martinez-Morcillo franciscojavier.martinez12@um.es

 Identification and validation of new therapeutic targets and prognosis markers for psoriasis.

Francisco J. Martinez-Navarro franciscojuan.martinez@um.es

 Identification and validation of new therapeutic targets and prognosis markers for psoriasis.

Elena Naranjo elena.naranjo1@um.es

 Role of TERC in glioblastoma

Irene Pardo-Sanchez irene.pardo1@um.es

 Role of oxidative stress and inflammation in melanoma 

Lola Rodriguez-Ruiz mariadolores.rodriguez10@um.es

.Impact of the inflammasome in hematopoiesis.
 
 

Master students

Manu Lozano juanmanuel.lozanog@um.es

.Impact of the inflammasome in hematopoiesis.
 

Technicians

Inmaculada Fuentes ifm@um.es

 Lab manager (UMU)

Inmaculada Lopez inmalopezmaya@hotmail.com

 Lab manager (IMIB)

Pedro J. Martinez pedrojmartinez@um.es

 Zebrafish facility manager (UMU)

Former lab's members

Dr. Pablo Pelegrin pablo.pelegrin@ffis.es

Dr. Jesus Garcia-Castillo jesus.garciac@umh.es

Dr. Gloria Lopez-Castejon Gloria.Lopez-Castejon@manchester.ac.uk

Dr. Elena Chaves-Pozo elena.chaves@mu.ieo.es

Dr. Ivan Mulero ivan.mulero@um.es

Dr. Jaya Kumari jaya_kumari2005@rediffmail.com

Dr. Francisco J. Roca froca@mrc-lmb.cam.ac.uk

Dr. Patricia Castillo-Briceño patricia.castillo-briceno@univmed.fr

Dr. Iciar Muñoz iciarmunoz@um.es

Dr. Sergio Liarte sdll1@um.es

Nicolas Gonzalez-Tejero ngm5@um.es

Ana Montalban ana.montalban-arques@medunigraz.at

Dr. Raquel Espin respin@um.es

Dr. Diego Angosto dangosto@um.es

Dr. Erick Garcia-Garcia dr.erick.garcia@gmail.com

Dr. Sofia de Oliveira sdeoliveira@wisc.edu

Dr. Jana Montero jana@um.es

Dr. Sergio Candel scandel@um.es

Dr. Chiara Gabellini donegal77@gmail.com

Dr. Han Mingming sealion1984@126.com

Dr. Sylwia Tyrkalska tyrkalska.sylwia@gmail.com

Dr. Jorge Galindo-Villegas jorge-galindo@um.es

Dr. Maricarmen Rodenas mariacarmen.rodenas1@um.es

Dr. Nuria E. Gomez-Gonzalez nuriaesther.gomez@um.es

Ana Valera anavap92@gmail.com

Sofia Ibañez sofiaibamol22@gmail.com

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Selected Publications

MULERO I, SEPULCRE MP, MESEGUER J, GARCIA-AYALA A, MULERO V (2007). Histamine is stored in mast cells of most evolutionarily advanced fish and regulates the fish inflammatory response. Proc Natl Acad Sci USA. 104: 19434-19439. Full text

ROCA FJ, MULERO I, LOPEZ-MUÑOZ A, SEPULCRE MP, MESEGUER J, MULERO V (2008). Evolution of the inflammatory response in vertebrates: fish TNFa is a powerful activator of endothelial cells but hardly activates phagocytes. J Immunol 181:5071-5081. Full text

ALCARAZ-PEREZ F, MULERO V, CAYUELA ML (2008). Application of the Dual-Luciferase Reporter Assay to the Analysis of Promoter Activity in Zebrafish Embryos. BMC Biotechnol 8:81. Full text

SEPULCRE MP, ALCARAZ-PÉREZ F, LÓPEZ-MUÑOZ A, ROCA FJ, MESEGUER J, CAYUELA ML, MULERO V (2009). Evolution of LPS Recognition and Signaling: Fish TLR4 Does Not Recognize LPS and Negatively Regulates NF-kB Activation. J Immunol. 182: 1836-1845 Full text

LÓPEZ-MUÑOZ A, ROCA FJ, MESEGUER J, MULERO V (2009). New insights into the evolution of IFNs: Zebrafish group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities. J Immunol 182: 3440-3449. Full text

OLAVARRÍA VH, SEPULCRE MP, FIGUEROA JE, MULERO V. (2010). Prolactin-induced production of ROS and IL-1b in leukocytes from the bony fish gilthead seabream involves Jak/Stat and NF-kB signaling pathways. J Immunol. 185:3873-3883. Full text

LÓPEZ-MUÑOZ A SEPULCRE MP, ROCA FJ, FIGUERAS A, MESEGUER J, MULERO V (2011). Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analysis. Mol. Immunol. 48:1073-1083. Full text

GALINDO-VILLEGAS J, GARCÍA-MORENO D, DE OLIVERIA S, MESEGUER J, MULERO V (2012). Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proc Natl Acad Sci USA 109: E2605-E2614. Full text. Full text Author Summary.

COMPAN V, BAROJA-MAZO A, LÓPEZ-CASTEJÓN G, GOMEZ AI, MARTÍNEZ CM, ANGOSTO D, MONTERO MT, HERRANZ AS, BAZÁN E, REIMERS D, MULERO V, PELEGRÍN P (2012). Cell volume regulation modulates NLRP3 inflammasome activation. Immunity 37:487-500. Full text.

ESPÍN R, ROCA FJ, CANDEL S, SEPULCRE MP, GONZÁLEZ-ROSA JM, ALCARAZ-PÉREZ F, MESEGUER J, CAYUELA ML, MERCADER N, MULERO V (2013). TNF receptors regulate vascular homeostasis through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Dis Model Mech 6:383-396. Full text.

DE OLIVEIRA S, REYES-ALDASORO CC, CANDEL S, RENSHAW SA, MULERO V, CALADO A. (2013). Cxcl8 (IL-8) mediates neutrophil recruitment and behavior in the zebrafish inflammatory response. J Immunol 190:4349-4359. Full text.

CABAS I, RODENAS MC, ABELLÁN E, MESEGUER J, MULERO V, GARCÍA-AYALA A. (2013). Estrogen signaling through the g protein-coupled estrogen receptor regulates granulocyte activation in fish. J Immunol 191:4628-4639. Full text.

ALCARAZ-PEREZ F, GARCIA-CASTILLO J, GARCIA-MORENO D, LOPEZ-MUNOZ A, ANCHELIN M, ANGOSTO D, ZON LI, MULERO V*, CAYUELA ML* (2014). A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish. Nat Commun 5:3228. Full text.

CANDEL S, DE OLIVEIRA S, LÓPEZ-MUÑOZ A, GARCÍA-MORENO D, ESPÍN-PALAZÓN R, TYRKALSKA SD, CAYUELA ML, RENSHAW SA, CORBALÁN R, VIDAL-ABARCA I, TSAI H-J, MESEGUER J, SEPULCRE MP, MULERO V. (2014). Tnfa Signaling Through Tnfr2 Protects Skin Against Oxidative Stress-Induced Inflammation. Plos Biol 12: e1001855. Full text.

DE OLIVEIRA S, LÓPEZ-MUÑOZ, A, CANDEL S, PELEGRIN P, CALADO A. MULERO V (2014). ATP modulates acute inflammation in vivo through dual oxidase 1-derived H₂O₂ production and NF-κB activation. J Immunol 192:5710-5719. Full text

ESPÍN-PALAZÓN R, STACHURA DL, CAMPBELL CA, GARCÍA-MORENO D, DEL CID N, KIM AD, CANDEL S, MESEGUER J, MULERO V, TRAVER D. (2014). Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell 159:1070-1085. Full text

DE OLIVEIRA S, LÓPEZ-MUÑOZ, A, MARTÍNEZ-NAVARRO FJ, GALINDO-VILLEGAS J, MULERO V, CALADO A (2014). Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium. Dev Comp Immunol 49:44-48. Full text

DE OLIVEIRA S, BOUDINOT P, CALADO A, MULERO V (2015). Duox1-Derived H₂O₂ Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications. J Immunol 194:1523-1533. Full text

GALINDO-VILLEGAS J, MONTALBAN-ARQUES A, LIARTE S, DE OLIVEIRA S, PARDO-PASTOR C, RUBIO-MOSCARDO F, MESEGUER J, VALVERDE MA, MULERO V (2016). Trpv4-mediated detection of hyposmotic stress by skin keratinocytes activates developmental immunity. J Immunol 196:738-749. Full text

TYRKALSKA SD, CANDEL S, ANGOSTO D, GÓMEZ-ABELLÁN V, MARTÍN-SÁNCHEZ F, GARCÍA-MORENO D, ZAPATA-PÉREZ R, SÁNCHEZ-FERRER A, SEPULCRE MP, PELEGRÍN P, MULERO V. (2016). Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins. Nat Commun 7:12077. Full text

ESPIN-PALAZON E, MARTÍNEZ-LÓPEZ A, ROCA FJ, LÓPEZ-MUÑOZ A, TYRKALSKA SD, CANDEL S, GARCÍA-MORENO D, FALCO A, MESEGUER J, ESTEPA A, MULERO V. (2016). TNFα impairs rhabdoviral clearance by inhibiting the host autophagic antiviral response. Plos Pathog 12(6):e1005699. Full text

CANDEL S, TYRKALSKA SD, GARCIA-MORENO D, MESEGUER J, MULERO V (2016). Identification of evolutionarily conserved Md1 splice variants that regulate innate immunity through differential induction of NF-кB. J Immunol 197(4):1379-88. Full text

RODENAS MC, TAMASSIA N, CABAS I, CALZETTI F, MESEGUER J, CASSATELLA MA, GARCÍA-AYALA A MULERO V (2017). G Protein-Coupled Estrogen Receptor 1 Regulates Human Neutrophil Functions. Biomed Hub 2: 454981. Full text

RODENAS MC, CABAS I, GÓMEZ-GONZÁLEZ NE, ARIZCUN M, MESEGUER J, MULERO V, GARCÍA-AYALA A. (2017). Estrogens Promote the Production of Natural Neutralizing Antibodies in Fish through G Protein-Coupled Estrogen Receptor 1. Front Immunol 8:736. Full text

ESPÍN-PALAZÓN R, WEIJTS B, MULERO V, TRAVER D (2018). Proinflammatory Signals as Fuel for the Fire of Hematopoietic Stem Cell Emergence. Trends Cell Biol 28:58-66. Full text

GABELLINI, C, GÓMEZ-ABENZA E, IBÁÑEZ-MOLERO S, TUPONE MG, PÉREZ-OLIVA AB, DE OLIVEIRA S, DEL BUFALO D, MULERO V. (2018). Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model. Int J Cancer 142:584-596. Full text

TYRKALSKA SD, CANDEL S, PÉREZ-OLIVA AB, VALERA A, ALCARAZ F, GARCÍA-MORENO D, CAYUELA ML, MULERO V. (2017). Identification of an evolutionarily conserved Ankyrin domain-containing protein, Caiap, which regulates inflammasome-dependent resistance to bacterial infection. Front Immunol 8:1375. Full text

LÓPEZ-MUÑOZ A, NICOLÁS FE, GARCÍA-MORENO D, PÉREZ-OLIVA AB, NAVARRO-MENDOZA MI, HERNÁNDEZ-OÑATE MA, HERRERA-ESTRELLA A, TORRES-MARTÍNEZ S, RUIZ-VÁZQUEZ RM, GARRE V, MULERO V. (2018). An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages. Sci Rep. 8:12802. Full text

MARTÍNEZ-NAVARRO FJ, MARTÍNEZ-MENCHÓN T, MULERO V GALINDO-VILLEGAS J,. (2019). Models of human psoriasis: Zebrafish the newly appointed player. Dev Comp Immunol. 97:76-87. Full text

GARCÍA-MORENO D, TYRKALSKA SD, VALERA-PÉREZ A, GÓMEZ-ABENZA E, PÉREZ OLIVA AB, MULERO V. (2019). The Zebrafish: A Research Model to Understand the Evolution of Vertebrate Immunity. Fish Shellfish Immunol. pii: S1050-4648(19)30305-5. doi: 10.1016/j.fsi.2019.04.067. Full text

TYRKALSKA SD, PÉREZ OLIVA AB, RODRÍGUEZ-RUIZ L, MARTÍNEZ-MORCILLO FJ, ALCARAZ-PÉREZ F, MARTÍNEZ-NAVARRO FJ, LACHAUD C, AHMED N, SCHROEDER T, PARDO-SÁNCHEZ I, CANDEL S, LÓPEZ-MUÑOZ A, CHOUDHURI A, ROSSMANN MP, ZON LI, CAYUELA ML, GARCÍA-MORENO D, MULERO V. (2019). Inflammasome regulates hematopoiesis through cleavage of the master erythroid transcription factor GATA1. Immunity 51:50-63. Full text

SEPAHI A, KRAUS A, CASADEI C, JOHNSTON CA, GALINDO-VILLEGAS J, KELLY C, GARCÍA-MORENO D, MUÑOZ P, MULERO V, HUERTAS M, SALINAS I. (en prensa). Olfactory sensory neurons mediate ultrarapid antiviral immune responses in a TrkA-dependent manner. PNAS 116:12428-12436. Full text

VALERA-PÉREZ A, TYRKALSKA SD, VIANA C, ROJAS-FERNÁNDEZ A, PELEGRÍN P, GARCÍA-MORENO D, PÉREZ-OLIVA AB, MULERO V. (2019). WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance. Dev Comp Immunol. doi: 10.1016/j.dci.2019.103428. Epub 2019 Jul 2. Full text

NOVOA B, PEREIRO P, LÓPEZ-MUÑOZ A, VARELA M, FORN-CUNÍ G, ANCHELIN M, DIOS S, ROMERO A, MARTINEZ-LÓPEZ A, MEDINA-GALI RM, COLLADO M, COLL J, ESTEPA A, CAYUELA ML, MULERO V, FIGUERAS A (2019). Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress. Aging Cell. 2019 Jul 26:e13020. doi: 10.1111/acel.13020. Full text

GÓMEZ-ABENZA E, IBÁÑEZ-MOLERO S, GARCÍA-MORENO D, FUENTES I, ZON LI, MIONE MC, CAYUELA ML, GABELLINI C, MULERO V (2019). Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment. J Exp Clin Cancer Res. 2019 Sep 13;38(1):405. doi: 10.1186/s13046-019-1389-3. Full text

Research grants

Our research is funded by:

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Positions available

No position are currently available.

Please contact us: vmulero@um.es

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Updated: October 2019