Research teams and lines (PhD in Integration and Modulation of Signals in Biomedicine)
- Research Team No. 1: Cell Biology and Histology.
- Research Team No. 2: Comparative Immunity.
- Research Team No. 3: Biochemistry.
- Research Team No. 4: Immunology.
- Research Team No. 5: Physiology, Nutrition, and Chronobiology.
- Research Team No. 6: Medical Physiology.
- Research Team No. 7: Cell Therapy and Translational Medicine.
- Research Team No. 8: Haematology and Experimental Clinical Oncology.
- Research Team No. 9: Legal Medicine and Toxicology.
- Research Team No. 10: Experimental Pharmacology.
- Research Team No. 11: Neuroscience.
Research Team No. 1: Cell Biology and Histology.
Research Line: Cell Biology of Intracellular Reproduction and Transport.
Description of the line: Studies on cell biology, histology, and bioethical aspects related to animal and human reproduction. On the other hand, the intracellular traffic is researched, especially the morpho-functional organisation of the Golgi apparatus in normal and pathological conditions.
Lecturers-Researchers:
Martínez Menárguez, José Ángel PhD.
Professional Status: Professor. Cell Biology Department, Faculty of Medicine, University of Murcia.
Ferrer Cazorla, Concepción PhD.
Professional Status: University Lecturer. Cell Biology Department, Faculty of Medicine, University of Murcia.
Martínez Alonso, Emma PhD.
Professional Status: Associate Professor. Cell Biology Department, Faculty of Medicine, University of Murcia.
Pastor García, Luis Miguel PhD.
Professional Status: Professor. Cell Biology Department, Faculty of Medicine, University of Murcia.
Madrid Cuevas, Juan Francisco PhD.
Professional Status: Professor. Cell Biology Department, Faculty of Medicine, University of Murcia.
Beltrán Frutos, Ester PhD.
Professional Status: Associate Professor. Cell Biology Department, Faculty of Medicine, University of Murcia.
Seco Rovira, Vicente PhD.
Professional Status: Associate Professor. Cell Biology Department, Faculty of Medicine, University of Murcia.
Research team No. 2: Comparative Immunity.
Research line: Evolution of Immune Responses in Vertebrates. Immunity, Inflammation, Angiogenesis, Haematopoiesis, and Cancer.
Description of the line: Immunity of teleost fish from a basic (evolution of immunity) and applied (aquaculture) point of view. Development of immunostimulants and vaccines. Immuno-reproductive interaction. Impact of inflammation in zebrafish using emerging techniques and developing new transgenic lines.
Research line: Immune System of Fish and Invertebrates. Effects of Environmental Contaminants on Immune Response.
Description of the line: Immune system in fish and invertebrates relevant for aquaculture. Inborn immune system, mucosal immunity, and diet enrichment. Interactions between the immune system, pathogens, and the aquatic environment. Effect of polluting agents on the immune response.
PLecturers-Researchers:
Mulero Méndez, Victoriano PhD.
Professional Status: Professor. Cell Biology and Histology. University of Murcia.
García Ayala, Alfonsa PhD.
Professional Status: Professor. Cell Biology and Histology. University of Murcia.
Esteban Abad, Mª Ángeles PhD.
Professional Status: University Lecturer. Cell Biology and Histology. University of Murcia.
Sepulcre Cortés, Mª Pilar PhD.
Professional Status: Associate Professor. Cell Biology and Histology. University of Murcia.
García Hernández, María del Pilar PhD.
Professional Status: University Lecturer. Cell Biology and Histology. University of Murcia.
Cuesta Peñafiel, Alberto PhD.
Professional Status: University Lecturer. Cell Biology and Histology. University of Murcia.
Guardiola Abellán, Francisco Antonio PhD.
Professional Status: Associate Professor. Cell Biology and Histology. University of Murcia.
Research team No. 3: Biochemistry.
Research line: Functional Regulation of Receptors Coupled to G Proteins.
Description of the line: This research team studies the regulation of cell proliferation and differentiation mediated by molecules derived from amino acids, such as peptide hormones, and polyamines. We analyse the role of the melanocortin 1 receptor (MC1R), with emphasis on the effect of natural mutations on signalling properties, intracellular trafficking, and increased risk of skin cancer.
Research line: Polyamines Metabolism and Cellular Regulation.
Description of the line: Studies on the regulation of ornithine decarboxylase (ODC), an enzyme that catalyses the limiting stage of the biosynthetic process of polyamines, as well as its regulatory proteins, antizymes (AZs) and antizyme inhibitors (AZINs). Both ODC and its regulatory proteins are related to processes of cell growth and differentiation, and are considered targets of antineoplastic agents.
Lecturers-Researchers:
Jiménez-Cervantes Frigols, Celia PhD.
Professional Status: University Lecturer. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia.
García-Borrón Martínez, José Carlos PhD.
Professional Status: Professor. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia.
Solano Muñoz, Francisco PhD.
Professional Status: Professor. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia.
Olivares Sánchez, Concepción PhD.
Professional Status: Associate Professor. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia.
Herraiz Serrano, Cecilia PhD.
Research Team No. 4: Immunology.
Research Line: Inflammatory Response in Infectious Diseases and Liver Cirrhosis.
Description of the line: Study of cell populations in infectious diseases and chronic and/or fibrotic inflammatory pathology, cellular signalling pathways, cytokine production, functional tests and analysis of other immunological parameters. Response to pathogens. Study of new drugs and therapeutic targets.
Research Line: Pathology of the Immune System. Cellular and Molecular Basis.
Description of the line: Pathophysiology of autoimmune diseases, hypersensitivity, immunodeficiencies, transplant rejection, infertility and tumours of immune origin. Animal models and diagnostic techniques.
Lecturers-Researchers:
Ruiz Alcaraz, Antonio PhD.
Professional Status: Associate Lecturer. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia.
Martínez Esparza Alvargonzalez, Mª Concepción PhD.
Professional Status: University Lecturer. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia.
Martín Orozco Santiago, Mª Elena PhD.
Professional Status: University Lecturer. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia.
Hernández Caselles, Trinidad PhD.
Professional Status: Associate Professor. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia.
Rubio Pedraza, Gonzalo PhD.
Professional Status: Associate Professor. Department of Biochemistry and Molecular Biology B and Immunology, Faculty of Medicine, University of Murcia.
Gimeno Arias, Lourdes PhD.
Professional Status: Associate Professor. Department of Human Anatomy and Psychobiology, Faculty of Medicine, Univeristy of Murcia.
Research Team No. 5: Physiology, Nutrition and Chronobiology.
Research Line: Nutrition, Food, and Metabolic Alterations.
Description of the line: Nutritional assessment in the elderly, nutrition during gestation and childhood. Nutritional intervention in adolescents to reduce the risk of metabolic syndrome. Functional Foods. Oxidative stress and prevention of aging and degenerative diseases. Foetal programming of nutrition-related diseases and effects on infant neurodevelopment.
Lecturers-Researchers:
López Olmeda, José Fernando PhD.
Professional status: Researcher: Ramón y Cajal
Research Line: Chronobiology and Aging.
Description of the line: Animal models for the study of aging. Integrated assessment of patient’s rhythms using non-invasive techniques (integration of blood-pressure registers, motor activity, body temperature, exposure to light, pupillometry, expression of clock genes and sleep-wake) in order to collaborate in improved diagnosis and treatment of disorders with a major circadian component such as aging, hypertension, diabetes, and sleep disorders.
Research Line: Aquaculture
Description of the line: Feeding strategies for fishes. Design of diets for fishes: alternative ingredients. Rhythms of dietary behaviour and dietary selection in fishes by self-demand. Nutritive use of dietary lipids in fishes. Environmental cycles and fish reproduction. Ontogenetic development of the fish clock.
Research Line: Obesity and Metabolic Syndrome.
Description of the line: Culture of adipocytes to study the expression of different genes and to be able to delve into the molecular functioning of human adipose tissue. Studies of nutrigenetics in obese patients and relationship with the alteration of the circadian rhythms. Nutritional intervention in obesity.
Lecturers-Researchers:
Madrid Pérez, Juan Antonio PhD.
Professional Status: Professor. Physiology, Faculty of Biology, University of Murcia.
Pérez Llamas, Francisca PhD.
Professional Status: University Lecturer. Physiology, Faculty of Biology, University of Murcia.
López Jiménez, José Ángel PhD.
Professional Status: University Lecturer. Physiology, Faculty of Biology, University of Murcia.
Sánchez Vázquez, Francisco Javier PhD.
Professional status: Professor. Physiology.
Larqué Daza, Elvira PhD.
Professional Status: University Lecturer. Physiology.
Marín Chicano, Juan Francisco PhD.
Professional Status: University Lecturer. Physiology.
Garaulet Aza, Marta PhD.
Professional status: Professor. Department of Physiology.
Rol de Lama, Ángeles PhD.
Professional Status: University Lecturer. Department of Physiology, Faculty of Biology, University of Murcia.
Mendiola López, Pilar PhD.
Professional Status: University Lecturer. Department of Physiology, Faculty of Biology, University of Murcia.
Martínez López, Francisco Javier PhD.
Professional Status: University Lecturer. Physiology, Faculty of Biology, University of Murcia.
Vera Andujar, Luisa María PhD.
Professional Status: Ramón y Cajal. Physiology, Faculty of Biology, University of Murcia.
Research Team No. 6: Medical Physiology.
Research line: Endothelial Dysfunction and Oxidative Stress in Cardiovascular and Renal Physiopathology.
Description of the line: This research line aims at establishing the importance of vascular endothelium and oxidative stress in cardiovascular and renal alterations of hypertension, renal damage secondary to ischemia, pre-eclampsia, type-1 diabetes and gestational diabetes.
Research line: Alterations of Nephrogenesis and its Implication in Renal Disease. Sexual Differences.
Description of the line: The objective of this line is the study of the mechanisms responsible for alterations in renal function and hypertension in adulthood, which appear as a consequence of a decreased number of nephrons in the perinatal stage.
Lecturers-Researchers:
Fenoy Palacios, Francisco J. PhD.
Professional Status: Professor. Department of Physiology, Faculty of Medicine, University of Murcia.
Hernández García, Isabel PhD.
Professional Status: University Lecturer. Department of Physiology, Faculty of Medicine, University of Murcia.
López Cano, Bernardo PhD.
Professional Status: University Lecturer. Department of Physiology, Faculty of Medicine, University of Murcia.
Dr. Llinás Más, M. Teresa PhD.
Professional Status: University Lecturer. Department of Physiology, Faculty of Medicine, University of Murcia.
Moreno Ayuso, Juan M. PhD.
Professional Status: Associate Professor. Department of Physiology, Faculty of Sport Sciences, University of Murcia.
Rodríguez Mulero, Francisca PhD.
Professional Status: University Lecturer. Department of Physiology, Faculty of Medicine, University of Murcia.
Salazar Aparicio, F. Javier PhD.
Professional status: Professor. Department of Physiology, Faculty of Medicine, University of Murcia.
Bonacasa Fernández, Bárbara PhD.
Professional Status: Associate Lecturer. Department of Physiology, Faculty of Medicine, University of Murcia
Research Team No. 7: Cell Therapy and Translational Medicine
Research Line: Cell Therapy and Haematopoietic Transplantation.
Description of the line: Stem cells, whether embryonic, induced pluripotent or adult, are a potentially unlimited source of cells for research or for clinical use in transplants. The ability of these cells to improve function or repair damaged tissues in disease animal models has contributed to generating high expectations in the development of new therapies for human diseases such as diabetes, Parkinson's and ischemic or degenerative diseases.
Research Line: Hypertension and Liver Cirrhosis.
Description of the line: Both diseases, arterial hypertension, and liver cirrhosis, share numerous humoral, cardiovascular and renal alterations, among others, which are relevant for the study of their pathophysiology. We are also interested in studying the role of vascular endothelium, free radicals and the effect of nutraceuticals and other drugs on the development and complications of these diseases.
Lecturers-Researchers:
García-Estañ López, Joaquín M. PhD.
Professional status: Professor. Department of Physiology, Faculty of Medicine, University of Murcia.
Iyú Espinosa, David C. PhD.
Professional Status: Associate Professor. Department of Physiology, Faculty of Medicine, University of Murcia.
Marín Atucha, Noemí T. PhD.
Professional Status: University Lecturer. Department of Physiology, Faculty of Medicine, University of Murcia.
Ortiz Ruiz, M. Clara PhD.
Professional Status: University Lecturer. Department of Physiology, Faculty of Medicine, University of Murcia.
Moraleda Jiménez, José María PhD.
Professional status: Professor. Department of Internal Medicine, Faculty of Medicine, University of Murcia.
Rodríguez Lozano, Francisco Javier PhD.
Professional Status: Associate Professor. Department of Dermatology, Stomatology, Radiology and Physical Medicine, Faculty of Medicine, University of Murcia.
Research Team No. 8: Haematology and Experimental Clinical Oncology.
Research Line: Haematology and Clinical Experimental Oncology.
Description of the line: Research with clear translational component, in the fields of clinical haematology, hematopoietic transplantation, thrombosis and haemostasis and oncology. The aim is to promote the acquisition of technological knowledge related to molecular biology, flow cytometry, cell biology, protein chemistry, haemostasis and thrombosis tests, aspects of genomics and clinical research methodology, among others, which will lead to experimental work in the field of Haematology and Oncology.
Lecturers-Researchers:
Vicente García, Vicente PhD.
Professional status: Professor. Department of Internal Medicine. University of Murcia.
Corral de la Calle, Javier PhD.
Professional Status: University Lecturer. Department of Internal Medicine. University of Murcia.
Lozano Almela, María Luisa PhD.
Professional Status: University Lecturer. Department of Internal Medicine. University of Murcia.
González Conejero Hilla, Rocío PhD.
Professional Status: University Lecturer. Department of Internal Medicine. University of Murcia.
Roldán Schilling, Vanessa PhD.
Professional Status: University Lecturer. Department of Internal Medicine. University of Murcia.
Ayala de la Peña, Francisco PhD.
Professional Status: Associate Lecturer. Department of Internal Medicine. University of Murcia.
Jerez Cayuela, Andrés PhD.
Professional Status: Associate Lecturer. Department of Internal Medicine. University of Murcia.
Research Team No. 9: Legal Medicine and Toxicology.
Research Line: Forensic Science and Human Toxicology.
Description of the line: New matrices and markers for the diagnosis of different causes of death and the circumstances in which it occurs. Tools for the diagnosis of drug and other toxic substance abuse in the medical and forensic field. Study of the factors that determine and define health alterations related to work. Ethical-legal implications of healthcare and research activities in biomedicine.
Lecturers-Researchers:
Pérez Cárceles, Mª Dolores PhD.
Professional status: Professor. Department of Social and Health Sciences, Faculty of Medicine, University of Murcia.
Falcón Romero, María PhD.
Professional Status: University Lecturer. Social and Health Sciences, Faculty of Medicine, University of Murcia.
Osuna Carrillo-Albornoz, Eduardo Javier PhD.
Professional status: Professor. Social and Health Sciences, Faculty of Medicine, University of Murcia.
Legaz Pérez, Isabel PhD.
Professional Status: Associate Lecturer. Social and Health Sciences, Faculty of Medicine, University of Murcia.
Hernández Romero, Diana PhD.
Professional Status: Associate Professor. Social and Health Sciences, Faculty of Medicine, University of Murcia.
Research Team No. 10: Experimental Pharmacology
Research Line: Molecular Mechanisms of Substance Abuse Addiction.
Description of the line: Molecular mechanisms involved in opiate addiction: microRNAs, transcription factors, glucocorticoids.
Research Line: Xenobiotic Pharmacokinetics.
Description of the line: Study of the pharmacokinetics of antibiotics and antiparasitics in domestic species: pharmacokinetic/pharmacodynamic integration. Study of modifications induced by polymer formulations for parenteral administration. In case of lactating animals: study of residue from these drugs.
Research Line: Cardiovascular Pharmacology: In vitro Study of Automatism Cardiac Contractility.
Description of the line: Study of cardiac contractility "in vitro" and its regulation by activating drugs of G proteins and inhibitors of phosphodiesterase. Study of normal and pathological cardiac function, modified by stimulation of G protein coupled receptors and the role of phosphodiesterase. Research on sinus and contractile myocardium of animal and human models (heart failure and atrial fibrillation).
Lecturers-Researchers:
Milanés Maquilón, Mª Victoria PhD.
Professional status: Professor.
Hernández Cascales, Jesús PhD.
Professional status: Professor.
Cárceles Rodríguez, Carlos M. PhD.
Professional status: Professor.
Escudero Pastor, Elisa PhD.
Professional status: Professor.
Martínez Martínez, José Antonio PhD.
Professional Status: University Lecturer.
Espuny Miró, Alberto PhD.
Professional Status: Associate lecturer.
Almela Rojo, Pilar PhD.
Professional Status: Associate lecturer.
Marín Carrillo, Pedro PhD.
Professional Status: Associate lecturer.
Núñez Parra, María Cristina PhD.
Professional Status: Part-time Associate lecturer.
Herrero Ezquerro, María Trinidad PhD.
Professional status: Professor.
Navarro Zaragoza, Javier PhD.
Professional Status: Associate Professor.
Research Team No. 11: Neuroscience.
Line of research: Development, Structure, and Evolution of the Nervous System.
Description of the line: Studies of the development and regionalisation of the brain based on molecular analysis and use maps. Evolutionary studies by comparative analysis of brain territories in different species. Functional study of genes using experiments of excess and lack of function (electroporation and analysis of mutants). Data mining of genes involved in normal and pathological neural development.
Lecturers-Researchers:
Aroca Tejedor, María del Pilar PhD.
Professional status: Professor. Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia.
Marín San Leandro, Faustino PhD.
Professional Status: University Lecturer. Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia.
Ferrán Bertone, José Luis PhD.
Professional Status: University Lecturer. Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia.
Research Line: Brain Aging and Dementias.
Description of the line: Development of anatomical and behavioural studies on normal and pathological brain aging in animal models. The anatomical studies are focused on the analysis of histochemical, immunocytochemical and connective markers in brain areas involved in cerebral aging processes, especially in the limbic system. At the same time, various behavioural tests (active avoidance, passive avoidance, labyrinth elevation in cross, Barnes labyrinth, cold immobilisation, cant-test) are applied to clarify different mechanisms inherent in memory, learning and emotional processes.
Lecturers-Researchers:
Popovic Popovic, Miroljub PhD.
Professional Status: University Lecturer. Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia.
García Calero, Elena PhD.
Professional Status: Associate Professor. Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia.
Alonso Fuentes, Mª Antonia Candelaria PhD.
Professional Status: Associate Professor. Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia.
