HORARIO: martes 10 de abril de 2018, a las 12:00
LUGAR: Salón de Grados, Facultad de Biología
TÍTULO: "Living in a data rich world: Using omics data to understand neurological diseases"
RESUMEN: Technological changes have driven a huge growth in the discovery of loci and genes that are causally associated with neurological diseases. This has been mirrored by an equally significant growth in the availability of data relating to gene structure and function, across human populations, tissues, cell types and disease states. However, the combination of locus heterogeneity and biological pleiotropy means that our molecular understanding of these diseases remains poor and to date these genetic discoveries have had minimal clinical impact. In this talk, I will discuss the use of a range of computational approaches, including co-expression network analysis and machine learning tools (ML) to leverage large, public omic datasets with the aim of finding hidden structure amongst genetic discoveries. In this way, I hope to show how these approaches have the potential to generate step changes in our understanding of neurological diseases and so help drive the identification of novel therapies.
PONENTE: Mina Ryten (MRC Clinician Scientist, University College London)
IDIOMA: inglés
DURACIÓN TOTAL ESTIMADA: 90 minutos
