Publicaciones
2017
The RNAi universe in Fungi: a varied landscape of small RNAs and biological functions Torres-Martinez S, Ruiz-Vazquez RM Annu Rev Microbiol. 2017; 8(71):371-391 (doi: 10.1146/annurev-micro-090816-093352) [PubMed] [Revisión] A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides Calo S, Nicolás FE, Lee SC, Vila A, Cervantes M, Torres-Martinez S, Ruiz-Vazquez RM, Cardenas ME, Heitman J PLoS Genet. 2017; 13(3):e1006686 (doi: 10.1371/journal.pgen.1006686) [PubMed] [Artículo] RNAi-based functional genomics identifies new virulence determinants in mucormycosis Trieu TA, Navarro-Mendoza MI, Pérez-Arques C, Sanchis M, Capilla J, Navarro-Rodriguez P, Lopez-Fernandez L, Torres-Martínez S, Garre V, Ruiz-Vázquez RM, Nicolás FE PLoS Pathog. 2017; 13(1):e1006150 (doi: 10.1371/journal.ppat.1006150) [PubMed] [PubMed Central] [Artículo]2016
Generation of lycopene-overproducing strains of the fungus Mucor circinelloides reveals important aspects of lycopene formation and accumulation Zhang Y, Chen H, Navarro E, López-García S, Chen YQ, Zhang H, Chen W, Garre V Biotechnol Lett. 2016; 39(3):439-446 (doi: 10.1007/s10529-016-2265-2) [PubMed] [Artículo] RNA interference in Fungi: retention and loss Nicolás FE, Garre V Microbiol Spectrum. 2016; 4(6) (doi: 10.1128/microbiolspec.FUNK-0008-2016) [PubMed] [Revisión] Expansion of signal transduction pathways in Fungi by extensive genome duplication Corrochano LM, Kuo A, Marcet-Houben M, Polaino S, Salamov A, Villalobos-Escobedo JM, Grimwood J, Álvarez MI, Avalos J, Bauer D, Benito EP, Benoit I, Burger G, Camino LP, Cánovas D, Cerdá-Olmedo E, Cheng JF, Domínguez A, Eliáš M, Eslava AP, Glaser F, Gutiérrez G, Heitman J, Henrissat B, Iturriaga EA, Lang BF, Lavín JL, Lee SC, Li W, Lindquist E, López-García S, Luque EM, Marcos AT, Martin J, McCluskey K, Medina HR, Miralles-Durán A, Miyazaki A, Muñoz-Torres E, Oguiza JA, Ohm RA, Olmedo M, Orejas M, Ortiz-Castellanos L, Pisabarro AG, Rodríguez-Romero J, Ruiz-Herrera J, Ruiz-Vázquez RM, Sanz C, Schackwitz W, Shahriari M, Shelest E, Silva-Franco F, Soanes D, Syed K, Tagua VG, Talbot NJ, Thon MR, Tice H, de Vries RP, Wiebenga A, Yadav JS, Braun EL, Baker SE, Garre V, Schmutz J, Horwitz BA, Torres-Martínez S, Idnurm A, Herrera-Estrella A, Gabaldón T, Grigoriev IV Curr Biol. 2016; 26(12):1577-1584 (doi: 10.1016/j.cub.2016.04.038) [PubMed] [Artículo] A new regulatory mechanism controlling carotenogenesis in the fungus Mucor circinelloides as a target to generate β-carotene over-producing strains by genetic engineering Zhang Y, Navarro E, Cánovas-Márquez JT, Almagro L, Chen H, Chen YQ, Zhang H, Torres-Martínez S, Chen W, Garre V Microb Cell Fact. 2016; 15:99 (doi: 10.1186/s12934-016-0493-8) [PubMed] [PubMed Central] [Artículo] RNAi pathways in Mucor: A tale of proteins, small RNAs and functional diversity Torres-Martínez S, Ruiz-Vázquez RM Fungal Genet Biol. 2016; 90:44-52 (doi: 10.1016/j.fgb.2015.11.006) [PubMed] [Revisión] Role of malate transporter in lipid accumulation of oleaginous fungus Mucor circinelloides Zhao L, Cánovas-Márquez JT, Tang X, Chen H, Chen YQ, Chen W, Garre V, Song Y, Ratledge C Appl Microbiol Biotechnol. 2016; 100(3):1297-1305 (doi: 10.1007/s00253-015-7079-y) [PubMed] [Artículo]2015
Distinct RNAi pathways in the regulation of physiology and development in the fungus Mucor circinelloides Ruiz-Vázquez RM, Nicolás FE, Torres-Martínez S, Garre V Adv Genet. 2015; 91:55-102 (doi: 10.1016/bs.adgen.2015.07.002) [PubMed] [Revisión] The RNAi machinery controls distinct responses to environmental signals in the basal fungus Mucor circinelloides Nicolás FE, Vila A, Moxon S, Cascales MD, Torres-Martínez S, Ruiz-Vázquez RM, Garre V BMC Genomics. 2015; 16:237 (doi: 10.1186/s12864-015-1443-2) [PubMed] [PubMed Central] [Artículo] A non-canonical RNA silencing pathway promotes mRNA degradation in basal Fungi Trieu TA, Calo S, Nicolás FE, Vila A, Moxon S, Dalmay T, Torres-Martínez S, Garre V, Ruiz-Vázquez RM PLoS Genet. 2015; 11(4):e1005168 (doi: 10.1371/journal.pgen.1005168) [PubMed] [PubMed Central] [Artículo] Comparison of biochemical activities between high and low lipid-producing strains of Mucor circinelloides: an explanation for the high oleaginicity of strain WJ11 Tang X, Chen H, Chen YQ, Chen W, Garre V, Song Y, Ratledge C PLoS One. 2015; 10(6):e0128396 (doi: 10.1371/journal.pone.0128396) [PubMed] [PubMed Central] [Artículo] Transformation of Mucor circinelloides f. lusitanicus protoplasts Garre V, Barredo JL, Iturriaga EA Genetic Transformation Systems in Fungi. 2015; 1:49-60 (doi: 10.1007/978-3-319-10142-2_4) [Capítulo de libro]2014
Antifungal drug resistance evoked via RNAi-dependent epimutations Calo S, Shertz-Wall C, Lee SC, Bastidas RJ, Nicolás FE, Granek JA, Mieczkowski P, Torres-Martínez S, Ruiz-Vázquez RM, Cardenas ME, Heitman J Nature. 2014; 513(7519):555-558 (doi: 10.1038/nature13575) [PubMed] [PubMed Central] [Artículo] The RNAi machinery in Mucorales: the emerging role of endogenous small RNAs Garre V, Nicolás FE, Torres-Martínez S, Ruiz-Vázquez RM Fungal RNA Biology. 2014; 12:291-313 (doi: 10.1007/978-3-319-05687-6_12) [Capítulo de libro]2013
A single argonaute gene participates in exogenous and endogenous RNAi and controls cellular functions in the basal fungus Mucor circinelloides Cervantes M, Vila A, Nicolás FE, de Haro JP, Moxon S, Dalmay T, Torres-Martínez S, Ruiz-Vázquez RM PLoS One. 2013; 8(7):e69283 (doi: 10.1371/journal.pone.0069283) [PubMed] [PubMed Central] [Artículo] Functional diversity of RNAi-associated sRNAs in fungi Nicolás FE, Ruiz-Vázquez RM Int. J. Mol. Sci. 2013; 14(8):15348-15360 (doi: 10.3390/ijms140815348) [PubMed] [PubMed Central] [Revisión] A White Collar 1-like protein mediates opposite regulatory functions in Mucor circinelloides Navarro E, Peñaranda A, Hansberg W, Torres-Martínez S, Garre V Fungal Genet Biol. 2013; 52:42-52 (doi: 10.1016/j.fgb.2012.12.003) [PubMed] [Artículo] Loss and retention of RNA interference in fungi and parasites Nicolás FE, Torres-Martínez S, Ruiz-Vázquez RM PLoS Pathog. 2013; 9(1):e1003089 (doi: 10.1371/journal.ppat.1003089) [PubMed] [PubMed Central] [Artículo] Malic enzyme activity is not the only bottleneck for lipid accumulation in the oleaginous fungus Mucor circinelloides Rodríguez-Frómeta RA, Gutiérrez A, Torres-Martínez S, Garre V Appl Microbiol Biotechnol. 2013; 97(7):3063-3072 (doi: 10.1007/s00253-012-4432-2) [PubMed] [Artículo]2012
Molecular tools for carotenogenesis analysis in the zygomycete Mucor circinelloides Torres-Martínez S, Ruiz-Vázquez RM, Garre V, López-García S, Navarro E, Vila A Methods Mol Biol. 2012; 898:85-107 (doi: 10.1007/978-1-61779-918-1_5) [PubMed] [Capítulo de libro] Protein kinase A regulatory subunit isoforms regulate growth and differentiation in Mucor circinelloides: essential role of PKAR4 Ocampo J, McCormack B, Navarro E, Moreno S, Garre V, Rossi S Eukaryot Cell. 2012; 11(8):989-1002 (doi: 10.1128/EC.00017-12) [PubMed] [PubMed Central] [Artículo] Biogenesis of Y RNA-derived small RNAs is independent of the microRNA pathway Nicolas FE, Hall AE, Csorba T, Turnbull C, Dalmay T FEBS Lett. 2012; 586(8):1226-1230 (doi: 10.1016/j.febslet.2012.03.026) [PubMed] [Artículo] Two distinct RNA-dependent RNA polymerases are required for initiation and amplification of RNA silencing in the basal fungus Mucor circinelloides Calo S, Nicolás FE, Vila A, Torres-Martínez S, Ruiz-Vázquez RM Mol Microbiol. 2012; 83(2):379-394 (doi: 10.1111/j.1365-2958.2011.07939.x) [PubMed] [Artículo]2011
mRNA expression profiling reveals conserved and non-conserved miR-140 targets Nicolas FE, Pais H, Schwach F, Lindow M, Kauppinen S, Moulton V, Dalmay T RNA Biol. 2011; 8(4):607-615 (doi: 10.4161/rna.8.4.15390) [PubMed] [Artículo] Bioengineering RNA silencing across the life kingdoms Alvarez-Fernandez R, Lopez-Gomollon S, Lopez-Martinez AF, Nicolas FE Recent Pat Biotechnol. 2011; 5(2):118-146 [PubMed] [Artículo] Experimental validation of microRNA targets using a luciferase reporter system Nicolas FE Methods Mol Biol. 2011; 732:139-152 (doi: 10.1007/978-1-61779-083-6_11) [PubMed] [Capítulo de libro] Silencing human cancer: identification and uses of microRNAs Nicolas FE, Lopez-Gomollon S, Lopez-Martinez AF, Dalmay T Recent Pat Anticancer Drug Discov. 2011; 6(1):94-105 [PubMed] [Revisión] Sporangiospore size dimorphism is linked to virulence of Mucor circinelloides Li CH, Cervantes M, Springer DJ, Boekhout T, Ruiz-Vazquez RM, Torres-Martinez SR, Heitman J, Lee SC PLoS Pathog. 2011; 7(6):e1002086 (doi: 10.1371/journal.ppat.1002086) [PubMed] [PubMed Central] [Artículo] High reliability transformation of the basal fungus Mucor circinelloides by electroporation Gutiérrez A, López-García S, Garre V J Microbiol Methods. 2011; 84(3):442-446 (doi: 10.1016/j.mimet.2011.01.002) [PubMed] [Artículo]2010
MicroRNAs in human diseases Nicolas FE, Lopez-Martinez AF Recent Pat DNA Gene Seq. 2010; 4(3):142-154 [PubMed] [Artículo] Endogenous short rnas generated by Dicer 2 and RNA-dependent RNA polymerase 1 regulate mrnas in the basal fungus Mucor circinelloides Nicolas FE, Moxon S, de Haro JP, Calo S, Grigoriev IV, Torres-Martínez S, Moulton V, Ruiz-Vázquez RM, Dalmay T Nucleic Acids Res. 2010; 38(16):5535-5541 (doi: 10.1093/nar/gkq301) [PubMed] [PubMed Central] [Artículo] Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level Pais H, Nicolas FE, Soond SM, Swingler TE, Clark IM, Chantry A, Moulton V, Dalmay T RNA. 2010; 16(3):489-94 (doi: 10.1261/rna.1701210) [PubMed] [PubMed Central] [Artículo] Photobiology in the Zygomycota: multiple photoreceptor genes for complex responses to light Corrochano LM, Garre V Fungal Genet Biol. 2010; 47(11):893-899 (doi: 10.1016/j.fgb.2010.04.007) [PubMed] [Revisión] Direct transformation of fungal biomass from submerged cultures into biodiesel Vicente V, Bautista LF, Gutiérrez FJ, Rodríguez R, Martínez V, Rodríguez-Frómeta RA, Ruiz-Vázquez RM, Torres-Martínez S, Garre V Energy & Fuels. 2010; 24(5):3173-3178 (doi: 10.1021/ef9015872) [Artículo]2009
A single dicer gene is required for efficient gene silencing associated with two classes of small antisense RNAs in Mucor circinelloides de Haro JP, Calo S, Cervantes M, Nicolás FE, Torres-Martínez S, Ruiz-Vázquez RM Eukaryot Cell. 2009; 8(10):1486-1497 (doi: 10.1128/EC.00191-09) [PubMed] [PubMed Central] [Artículo] RNA silencing: Recent developments on miRNAs Nicolas FE, Lopez-Gomollon S, Lopez-Martinez AF, Dalmay T Recent Pat DNA Gene Seq. 2009; 3(2):77-87 [PubMed] [Revisión] Transcriptional activation increases RNA silencing efficiency and stability in the fungus Mucor circinelloides Nicolás FE, Torres-Martínez S, Ruiz-Vázquez RM. J Biotechnol. 2009; 142(2):123-126 (doi: 10.1016/j.jbiotec.2009.04.003) [PubMed] [Artículo] A subunit of protein kinase a regulates growth and differentiation in the fungus Mucor circinelloides Ocampo J, Fernandez Nuñez L, Silva F, Pereyra E, Moreno S, Garre V, Rossi S Eukaryot Cell. 2009; 8(7):933-944 (doi: 10.1128/EC.00026-09). Erratum in: Eukaryot Cell. 2012; 11(7):963 [PubMed] [PubMed Central] [Artículo] Biodiesel production from biomass of an oleaginous fungus Vicente V, Bautista LF, Rodríguez R, Gutiérrez FJ, Sádaba I, Ruiz-Vázquez RM, Torres-Martínez S, Garre V Biochem Eng J 2009; 48(1):22-27 [Artículo]2008
Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140 Nicolas FE, Pais H, Schwach F, Lindow M, Kauppinen S, Moulton V, Dalmay T RNA. 2008; 14(12):2513-2520 (doi: 10.1261/rna.1221108) [PubMed] [PubMed Central] [Artículo] Microsporidia evolved from ancestral sexual fungi Lee SC, Corradi N, Byrnes EJ III, Torres-Martinez S, Dietrich FS, Keeling PJ, Heitman J Curr Biol. 2008; 18(21):1675-1679 (doi: 10.1016/j.cub.2008.09.030) [PubMed] [PubMed Central] [Artículo] A RING-finger protein regulates carotenogenesis via proteolysis-independent ubiquitylation of a white collar-1-like activator Silva F, Navarro E, Peñaranda A, Murcia-Flores L, Torres-Martínez S, Garre V Mol Microbiol. 2008; 70(4):1026-1036 (doi: 10.1111/j.1365-2958.2008.06470.x) [PubMed] [Artículo] Role of the white collar 1 photoreceptor in carotenogenesis, UV resistance, hydrophobicity, and virulence of Fusarium oxysporum Ruiz-Roldán MC, Garre V, Guarro J, Mariné M, Roncero MI Eukaryot Cell. 2008; 7(7):1227-1230 (doi: 10.1128/EC.00072-08) [PubMed] [PubMed Central] [Artículo] A RING-finger photocarotenogenic repressor involved in asexual sporulation in Mucor circinelloides Nicolás FE, Calo S, Murcia-Flores L, Garre V, Ruiz-Vázquez RM, Torres-Martínez S FEMS Microbiol Lett. 2008; 280(1):81-88 (doi: 10.1111/j.1574-6968.2007.01044.x) [PubMed] [Artículo] Lycopene over-accumulation by disruption of the negative regulator gene crgA in Mucor circinelloides Nicolás-Molina FE, Navarro E, Ruiz-Vázquez RM Appl Microbiol Biotechnol. 2008; 78(1):131-137 [PubMed] [Artículo]2007
Non-AUG translation initiation of a fungal RING finger repressor involved in photocarotenogenesis Murcia-Flores L, Lorca-Pascual JM, Garre V, Torres-Martínez S, Ruiz-Vázquez RM J Biol Chem. 2007; 282(21):15394-15403 [PubMed] [Artículo] Mutants defective in a Mucor circinelloides dicer-like gene are not compromised in siRNA silencing but display developmental defects Nicolás FE, de Haro JP, Torres-Martínez S, Ruiz-Vázquez RM Fungal Genet Biol. 2007; 44(6):504-16 [PubMed] [Artículo]2006
Distinct white collar-1 genes control specific light responses in Mucor circinelloides Silva F, Torres-Martínez S, Garre V Mol Microbiol. 2006; 61(4):1023-1037 [PubMed] [Artículo]2005
Light induction of the carotenoid biosynthesis pathway in Blakeslea trispora Quiles-Rosillo MD, Ruiz-Vázquez RM, Torres-Martínez S, Garre V Fungal Genet Biol. 2005; 42(2):141-153 [PubMed] [Artículo]2004
The RING-finger domain of the fungal repressor crgA is essential for accurate light regulation of carotenogenesis Lorca-Pascual JM, Murcia-Flores L, Garre V, Torres-Martínez S, Ruiz-Vázquez RM Mol Microbiol. 2004; 52(5):1463-1474 [PubMed] [Artículo]2003
Two classes of small antisense RNAs in fungal RNA silencing triggered by non-integrative transgenes Nicolás FE, Torres-Martínez S, Ruiz-Vázquez RM EMBO J. 2003; 22(15):3983-3991 [PubMed] [PubMed Central] [Artículo] Cloning, characterization and heterologous expression of the Blakeslea trispora gene encoding orotidine-5'-monophosphate decarboxylase Quiles-Rosillo MD, Ruiz-Vázquez RM, Torres-Martínez S, Garre V FEMS Microbiol Lett. 2003; 222(2):229-236 [PubMed] [Artículo] cigA, a light-inducible gene involved in vegetative growth in Mucor circinelloides is regulated by the carotenogenic repressor crgA Quiles-Rosillo MD, Torres-Martínez S, Garre V Fungal Genet Biol. 2003; 38(1):122-132 [PubMed] [Artículo]2001
A negative regulator of light-inducible carotenogenesis in Mucor circinelloides Navarro E, Lorca-Pascual JM, Quiles-Rosillo MD, Nicolás FE, Garre V, Torres-Martínez S, Ruiz-Vázquez RM Mol Genet Genomics. 2001; 266(3):463-470 [PubMed] [Artículo]2000
Overexpression of the crgA gene abolishes light requirement for carotenoid biosynthesis in Mucor circinelloides Navarro E, Ruiz-Pérez VL, Torres-Martínez S Eur J Biochem. 2000; 267(3):800-807 [PubMed] [Artículo]1995
Mutants of the carotenoid biosynthetic pathway of Mucor circinelloides Navarro E, Sandmann G, Torres-Martínez S Exp Mycol. 1995; 19(3):186-190 [Artículo]
