Grupo de Investigación de MetalofármacosUniversidad de Murcia |
Catedrático de Universidad |
MIEMBROS María Dolores Santana Lario (C.U.) Natalia Mª Sagrado Corazón Cutillas Aulló (C.E.) María Concepción De Haro García (T.U.) Venanacio Rodríguez Hernández (T.U.) Consolación Vicente López (T.U.) Francisco José Ballester Hernández (CO) Alaba Hernández García (CO) Antonio Linero Artiaga (CO) Alicia Marco Calero (CO) Enrique Ortega Forte (CO) Mª José Piernas Muñoz (CO) Gloria Vigueras Bautista (CO) Pezhman Ashoo (COL) |
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Investigación
LÍNEAS - Estudio de la interacción de metalodrogas con DNA y proteínas. - Preparación de nuevas metalodrogas antitumorales. |
PROYECTOS - PID2021-122850NB-I00 Diseño de complejos metálicos multifuncionales para la fototerapia de celulas madre tumorales. |
Últimos artículos
Portada en: JOURNAL OF MEDICINAL CHEMISTRY Volume 67 | Number 10 | 23 May 2024 |
Novel Re(I) Complexes as Potential Selective Theranostic Agents in Cancer Cells and In Vivo in Caenorhabditis elegans Tumoral Strains. Alicia Marco; Pezhman Ashoo; Samanta Hernández-García; Pedro Martínez-Rodríguez; Natalia Cutillas; Annette Vollrath; Dustin Jordan; Christoph Janiak; Fernando Gandía-Herrero; José Ruiz. Journal of Medicinal Chemistry. 67, 10, 7891–7910 (2024). DOI:10.1021/acs.jmedchem.3c01869 | ![]() |
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New Cyclometalated Ru(II) Polypyridyl Photosensitizers Trigger Oncosis in Cancer Cells by Inducing Damage of Cellular Membranes. Jakub Cervinka; Alba Hernández-García; Delia Bautista; Lenka Marková; Hana Kostrhunova; Jaroslav Malina; Jana Kasparkova; M. Dolores Santana; Viktor Brabec; Jose Ruiz. Inorganic Chemistry Frontiers (2024). DOI: 10.1039/d4qi00732h |
Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells. Jana Kasparkova; Vojtech Novohradsky; José Ruiz; Viktor Brabec. Chemico-Biological Interactions. 392:110921 (2024). DOI:10.1016/j.cbi.2024.110921 | ![]() |
Portada en: INORGANIC CHEMISTRY Volume 63 | Number 14 | 8 April 2024 |
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Photoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1,2,3-triazole Chelators for Cancer Treatment. Francisco J. Ballester; Alba Hernández-García; M. Dolores Santana; Delia Bautista; Pezhman Ashoo; Enrique Ortega-Forte; Giampaolo Barone; José Ruiz. Inorganic Chemistry. 63, 14, 6202–6216 (2024). DOI: 10.1021/acs.inorgchem.3c04432 |
Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis. Jana Kasparkova, Alba Hernández-García, Hana Kostrhunova, Marta Goicuría, Vojtec Novohradsky, Delia Bautista, Lenka Markova, María Dolores Santana, Viktor Brabec and José Ruiz. J. Med. Chem. 67, 1, 691–708 (2024). DOI:10.1021/acs.jmedchem.3c01978 | ![]() |
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A near-infrared light-activatable Ru(<scp>ii</scp>)-coumarin photosensitizer active under hypoxic conditions. Enrique Ortega-Forte, Anna Rovira, Marta López-Corrales, Alba Hernández-García, Francisco José Ballester, Eduardo Izquierdo-García, Mireia Jordà-Redondo, Manel Bosch, Santi Nonell, María Dolores Santana, José Ruiz, Vicente Marchán and Gilles Gasser. Chem. Sci. 14, 7170-7184 (2023). DOI: 10.1039/D3SC01844J |
Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria. Alicia Marco, Gloria Vigueras, Natalia Busto, Natalia Cutillas, Delia Bautista and José Ruiz. Dalton Trans. 52, 13482-13486 (2023). DOI:10.1039/D3DT01678A | ![]() |
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Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells. Vojtech Novohradsky, Alicia Marco, Lenka Markova, Natalia Cutillas, José Ruiz and Viktor Brabec. J. Med. Chem. 66, 14, 9766–9783 (2023). DOI: 10.1021/acs.jmedchem.3c00586 |
Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates. Anna Rovira, Martí i Franquès, Enrique Ortega-Forte, Cormac Hally, Mireia Jordà-Redondo, Diego Abad-Montero, Gloria Vigueras, Jesús I. Martínez, Manel Bosch, Santi Nonell, José Ruiz and Vicente Marchán. J. Med. Chem. 66, 12, 7849–7867 (2023). DOI: 10.1021/acs.jmedchem.3c00189 | ![]() |
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Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis. Alba Hernández-García, Lenka Marková, María Dolores Santana, Jitka Prachařová, Delia Bautista, Hana Kostrhunová, Vojtěch Novohradský, Viktor Brabec, José Ruiz and Jana Kašpárková. Inorg. Chem. 62, 16, 6474–6487 (2023). DOI: 10.1021/acs.inorgchem.3c00501 |
Newly synthesized benzothiazolyl-1,2,3-triazole derivatives: Intramolecular charge transfer tuning, solvatofluorochromism and antiproliferative properties. F. J. Ballester; E. Ortega-Forte; D. Bautista; M. D. Santana; G. Barone; J. Ruiz. Dyes and Pigments, 209-A, 110905 (2023). DOI: 10.1016/j.dyepig.2022.110905 | ![]() |