José Ruiz López
Departamento de Química Inorgánica - Universidad de Murcia
English version 
English version
Novel Re(I) Complexes as Potential Selective Theranostic Agents in Cancer Cells and In Vivo in Caenorhabditis elegans Tumoral Strains. Alicia Marco; Pezhman Ashoo; Samanta Hernández-García; Pedro Martínez-Rodríguez; Natalia Cutillas; Annette Vollrath; Dustin Jordan; Christoph Janiak; Fernando Gandía-Herrero; José Ruiz. Journal of Medicinal Chemistry. 2024, 67, 10, 7891–7910. DOI:10.1021/acs.jmedchem.3c01869.PORTADA. Photoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1,2,3-triazole Chelators for Cancer Treatment. Francisco J. Ballester; Alba Hernández-García; M. Dolores Santana; Delia Bautista; Pezhman Ashoo; Enrique Ortega-Forte; Giampaolo Barone; José Ruiz. Inorganic Chemistry. 63, 14, 6202–6216 (2024). DOI: 10.1021/acs.inorgchem.3c04432.PORTADA. Polyurethane–polyurea hybrid nanocapsules as efficient delivery systems of anticancer Ir(III) metallodrugs. Joaquín Bonelli, Enrique Ortega-Forte, Gloria Vigueras, Manel Bosch, Natalia Cutillas, Josep Rocas, José Ruiz and Vicente Marchán. Inorg. Chem. Front., 2022, 9, 2123. DOI: 10.1039/D1QI01542G. PORTADA. Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage. Ana Zamora, Catherine A. Denning, David K. Heidary, Erin Wachter, Leona A. Nease, José Ruiz y Edith C. Glazer. Dalton Trans. 2017, 46, 2165-2173. DOI: 10.1039/C6DT04405K Highly potent extranuclear-targeted luminescent iridium(iii) antitumor agents containing benzimidazole-based ligands with a handle for functionalization. J. Yellol, S. A. Pérez, G. Yellol, J. Zajac, A. Donaire, G. Vigueras, V. Novohradsky, C. Janiak, V. Brabec, J. Ruiz, Chem. Commun., 2016, 52, 14165 - 14168. DOI: 10.1039/c6cc07909a Antitumor Properties of Platinum(IV) Prodrug-Loaded Silk Fibroin Nanoparticles. A. Abel Lozano-Pérez, Ana L. Gil, Sergio A. Pérez,b Natalia Cutillas, Hajo Meyer, Mónica Pedreño, Salvador Aznar-Cervantes, Christoph Janiak, Jose Luis Cenis, and José Ruiz. Dalton Trans. 2015, Vol. 44, XXX. DOI: 10.1039/C5DT00378D On the antitumor properties of novel cyclometalated benzimidazole Ru(II), Ir(III) and Rh(III) complexes. Gorakh S. Yellol, Antonio Donaire, Jyoti G. Yellol, Vera Vasylyeva, Christoph Janiak and José Ruiz. Chem. Commun. 2013, 49, 11533-11535. DOI: 10.1039/C3CC46239K Novel Bis-C,N-Cyclometalated Iridium(III) Thiosemicarbazide Antitumor Complexes: Interactions with Human Serum Albumin and DNA, and Inhibition of Cathepsin B. José Ruiz, Consuelo Vicente, Concepción de Haro and Delia Bautista. Inorg. Chem. 2013, 52, 974-982. DOI: 10.1021/ic302219v Novel C,N-chelate rhodium(III) and iridium(III) antitumor complexes incorporating a lipophilic steroidal conjugate and their interaction with DNA. José Ruiz, Venancio Rodríguez, Natalia Cutillas, Katia G. Samper, Mercè Capdevila , Òscar Palacios and Arturo Espinosa. Dalton Trans., 2012, 41, 12847-12856. DOI: 10.1039/c2dt31654d A potent ruthenium(II) antitumor complex bearing a lipophilic levonorgestrel group. Ruiz José, Rodríguez Venancio, Cutillas Natalia, Espinosa Arturo, Hannon Michael J. Inorg. Chem. 2011; 50(18): 9164-71. DOI: 10.1021/ic201388n Novel C,N-chelate platinum(II) antitumor complexes bearing a lipophilic
ethisterone pendant. Synthesis and Antiproliferative Activity of a C,N-Cycloplatinated(II)
Complex with a Potentially Intercalative Anthraquinone Pendant. η5-Cyclopentadienylpalladium(II) complexes: Synthesis, characterization and use
for the vinyl addition polymerization of norbornene and the copolymerization
with 5-vinyl-2-norbornene or 5-ethylidene-2-norbornene. New 7-azaindole palladium and platinum complexes: crystal structures and
theoretical calculations. In vitro anticancer activity of the platinum
compounds. A novel ruthenium(II) arene based intercalator with potent anticancer activity. N1-Coordination in New Palladium(II) and Platinum(II) Complexes with
the Model Nucleobase 9-methylhypoxanthine: First Crystal Structure and Theoretical Calculations. |
"Pentafluorophenyl derivatives of palladium(II) and platinum(II) with O-donor ligands"
G. López, G. García, N. Cutillas y J. Ruiz. Journal of Organometallic Chemistry , 1983, 241, 269-273.
"Chemical behaviour of tetrahydrofuran in the presence of the Pd(C6F5)2 moiety"
G. López, G. García, J. Ruiz y N. Cutillas. Journal of Organometallic Chemistry , 1983, 246, C83-C84.
"Trialkylsilyl (Hydrido) (ethylene) pentamethylcyclopentadienyl rhodium(III) complexes"
P.O. Bent, J. Ruiz, B.E. Mann, C.M. Spencer y P.M. Maitlis. J. Chem. Soc., Chem. Comm, 1985,1374-1375
"Replacement of alkyl by alkoxy on silicon attached to rhodium"
J. Ruiz y P. MaitlisJ. Chem. Soc, Chem. Comm., 1986, 862-863
"The synthesis and characterisation of di-hydrido-bis(trialkyltin)(pentamethylcyclopentadienyl)-rhodium(V) and -iridium(V) complexes and related reactions"
J. Ruiz, C.M. Spencer, B.E. Mann, B.F. Taylor y P.M. MaitlisJ. Organomet. Chem., 1987, 325, 253-260
"Binuclear rhodium and iridium complexes containing pentamethylcyclopentadienyl and pyrazolate ligands"
D. Carmona, L.A. Oro, M.P. Lamata, M.P. Puebla, J. Ruiz y P.M. Maitlis. J. Chem. Soc., Dalton Trans., 1987, 639-645
"Reactions of rhodium(V) hydrido-silyl complexes with butyl-lithium and with lithium triethylhydridoborate"
J. Ruiz, B.E. Mann, C.M. Spencer, B.F. Taylor y P.M. Maitlis. J. Chem. Soc, Dalton Trans., 1987, 1963-1966
"The synthesis and the structure determination of a novel η 6-arene rhodium(III) complex, [(Me2SiC6H5)4Rh2H2], and the synthesis of"
M.J. Fernández, M.A. Esteruelas, L.A. Oro, J.Ruiz, A.J. Smidth y P.M. Maitlis. J. Organomet. Chem., 1987, 330, 179-184
"The formation and characterisation of hydrido (η2-ethene) (tri-substituted silyl) pentamethylcylopentadienyl rhodium complexes; Intermediates in catalytic dehydrogenative silylation reactions"
J. Ruiz, P.O. Bentz, B.E. Mann, C.M. Spencer, B.F. Taylor y P.M. Maitlis. J. Chem. Soc., Dalton Trans., 1987, 2709-2713
"K2[Pd(C6F5)4]- Catalyzed cyclotrimerization of malononitrile"
G. López, G. Sánchez, G. García, J. Gálvez y J. Ruiz. Journal of Organometallic Chemistry, 1987, 321, 273-278.
"Hydroxo-organo-complexes of the nickel group elements"
G. López, G. García, J. Ruiz, G. Sánchez, J. García y C. Vicente. J. Chem. Soc., Chemical Communications, 1989, 1045-1046.
"Synthesis and structural study of neutral mononuclear and anionic binuclear 2,4,6-trifluorophenyl derivatives of palladium(II). Crystal structure of [P(CH2Ph)Ph3]2[(C6F3H2)2Pd(μ-SCN)(μ-NCS)Pd(C6F3H2)2]"
G. López, G. García, M.D. Santana, G. Sánchez, J. Ruiz, A. Hermoso, A. Vegas y M Martínez-Ripoll. J. Chem. Soc., Dalton Transactions, 1990, 1621-1626.
"Binuclear hydroxo-monopentahalophenyl complexes palladium(II)"
G. López, J. Ruiz, G. García, C. Vicente, J. M. Martí y M. D. SantanaJournal of Organometallic Chemistry, 1990, 359, C53-C55.
"Nickel-catalyzed cyclotrimerization of malononitrile. Synthesis and molecular structure of a dicyanomethanide bridged nickel(II) complex, [{Ni(C6F5)2(μ-NCCHCN)}2]2-"
G. López, G. Sánchez, G. García, J. Ruiz, J. García, M. Martínez-Ripoll, A. Vegas y J.A. Hermoso. Angewandte Chemie, International Edition in English, 1991, 30, 716-718.
"Synthesis, structural characterization, and reactivity toward some weak, protic electrophiles of [(C6F5)2Pd(μ-OH)2Pd(C6F5)2]2-"
G. López, J. Ruiz, G. García, C. Vicente, J. Casabó, E. Molins y C. Miravitlles. Inorganic Chemistry, 1991, 30, 2605-2610.
"Synthesis and reactivity of the di-μ-hydroxo-bis[bis(pentachlorophenyl) palladate(II)] ion"
G. López, J. Ruiz, G. García, J.M. Martí, G. Sánchez y J. García. Journal of Organometallic Chemistry, 1991, 412, 4355-443.
"Synthesis and reactivity towards some weak, protic acids of the di-μ-hydroxo-bis[bis(2,4,6-trifluorophenyl) palladate(II)] ion"
G. López, G. García, G. Sánchez, M.D. Santana, J. Ruiz y J. García. Inorganica Chimica Acta, 1991, 188, 195-200.
"Synthesis and Reactivity of Hydroxo-bridged Binuclear Platinum Complexes. Crystal Structure of [NBu4]2[{Pt(C6F5)2(μ-OH)}2]"
G. López, J. Ruiz, G. García, C. Vicente, J.M. Martí, J.A. Hermoso, A. Vegas y M. Martínez-Ripoll. J. Chem. Soc., Dalton Transactions, 1992, 53-58.
"Hydroxo and azolate pentafluorophenyl derivatives of nickel(II). Crystal Structure of (NBu4)2 [{Ni(C6F5)2(μ-OH)}2] and (NBu4)2 [{Ni(C6F5)2}2(μ-OH)(μ-pyrazolate)]"
G. López, G. García, G. Sánchez, J. García, J. Ruiz, J.A. Hermoso, A. Vegas y M. Martínez- Ripoll. Inorganic Chemistry, 1992, 31, 1518-1523.
"New methoxo-, Hydroxo- and pyrazolate-bridged platinum(II) complexes. Crystal Structure of (NBu4)2[{Pt(C6F5)2}2(μ-OH)(μ-dmpz)] (dmpz = 3,5-dimethylpyrazolate)"
G. López, J. Ruiz, G. García, C. Vicente, V. Rodríguez, G. Sánchez, J. Hermoso y M. Martínez-Ripoll. J. Chem. Soc., Dalton Transactions, 1992, 1681-1686.
"Synthesis of palladium(II) and platinum(II) N,N-dialkyldithiocarbamates starting from hydroxo-halophenyl complexes"
G. López, J. Ruiz, G. García, C. Vicente, J.M. Martí y V. Rodríguez. Journal of Organometallic Chemistry, 1992, 436, 121-126.
"Synthesis and characterization of mononuclear pyrazolyl complexes of palladium(II) and platinum(II). Crystal structures of [NBu4] [M(C6F5)2(pyrazole)(pyrazolate)] (M = Pd, Pt)"
G. López, J. Ruiz, C. Vicente, J.M. Martí, G. García, P.A. Chaloner, P.B. Hitchcock y R.M. Harrison. Organometallics, 1992, 11, 4090-4096.
"Synthesis and characterization of hydroxo, pyrazolate and carboxilate derivates of the PdR(PPh3) moiety (R = C6F5or C6Cl5)
J. Ruiz, C. Vicente, J.M. Martí, N. Cutillas, G. García y G. López. Journal of Organometallic Chemistry, 1993, 460, 241-248.
"Synthesis and characterization of arylamide-bridged binuclear palladium(II) complexes. Crystal structures of anti -[{Pd(C6F5)(t -BuNC)(m-NHPh)2]"
J. Ruiz, M.T. Martínez, C. Vicente, J.M. Martí, G. García, G. López, P.A. Chaloner y P.B. Hitchcock. Organometallics, 1993, 12, 4321-4326.
"Synthesis and Structural Study of [{Pd(CH2C9H6N)}2(m-O2CR)(m-X)] Complexes (R = Me or CF3; X = Hidroxide, Amide or Thiolate)"
J. Ruiz, N. Cutillas, J. Torregrosa, G. García, G. López, P.A. Chaloner, P.B. Hitchcock and R.M. Harrison. J. Chem. Soc., Dalton Transactions, 1994, 2353-2357.
"Pentahalophenyl palladium and platinum trinuclear complexes with tetrathiomolybdate and tetrathiotungstate ligands"
J. Ruiz, V. Rodríguez, G. López, P.A. Chaloner y P.B. Hitchcock. Journal of Organometallic Chemistry, 1995, 493, 77-82
"Synthesis and of binuclear bis(μ-aryloxo)complexes of palladium and platinum. Crystal structure of
[NBu4][Pt(C6F5)2(OC6H4NO2-p)(CO)]."
J. Ruiz, V. Rodríguez, G. López, P.A. Chaloner y P.B. Hitchcock. Organometallics, 1996, 15, 1662-1668
Novel β-iminoenolate (or β-carbonyliminate) complexes starting from di-μ-hydroxo palladium or platinum complexes with dimethyl acetylenedicarboxylate and primary amines. Crystal structure of [NBu4][(C6F5)2Pd{N(C6H4NO2-p)C(CO2Me)CHC(O)OMe].
J. Ruiz, V. Rodríguez, G. López, P.A. Chaloner y P.B. Hitchcock. Journal of Organometallic Chemistry, 1996, 523, 23-32
Synthesis and structural study of [{Pd(C6H4CH2N(CH3)2)}2(μ-Br)(μ-X) complexes (X = hydroxide, amide or thiolate).
J. Ruiz, N. Cutillas, J. Sampedro, G. López, J. A. Hermoso, M. Martínez Ripoll. Journal of Organometallic Chemistry, 1996, 526, 67-72
Reactivity of hydroxo palladium and platinum complexes towards N-substituted salicylaldimines and β-ketoimines.
J. Ruiz, V. Rodríguez, C. Vicente y G. López. Transition Metal Chemistry, 1997, 22, 502-506
Synthesis and reactivity of [Pd2L2R2(μ-OH)2]- type complexes (L= PEt3, PPh3; R= Me, PhCH2, Ph). Crystal structure of [Pd2(PPh3)2(μ-OH)(μ-C6H4OMe-p)].
J. Ruiz, V. Rodríguez, G. López, P.A. Chaloner y P.B. Hitchcock. J. Chem. Soc., Dalton Transactions, 1997, 4271-4276
New aliphatic and aromatic thiolato-bridged complexes of palladium(II) and platinum(II)
J. Ruiz, C. Vicente, V. Rodríguez y G. López. Polyhedron, 1998, 17, 1503-1509
Reactivity of [NBu4]2[{(C6F5)2M(μ-OH)}2] (X = F or Cl; M = Pd or Pt) towards heterocyclic thiones: crystal structure of [NBu4]2[{(C6F5)2Pd(μ-h2-LL')}2] (LL' = methylimidazole-2-thiolate)
J. Ruiz, F. Florenciano, G. López, P. A. Chaloner, P.B. Hitchcock. Inorganica Chimica Acta, 1998, 281, 165-173
Reactivity of [{M(C6F5)2(μ-OH)}2]2- (M= Pd or Pt) towards aromatic amines and malononitrile
J. Ruiz, V. Rodríguez, G. López, J. Casabó, E. Molins y C. Miravitlles. Organometallics, 1999, 18, 1177-1184 Esquema
Reactivity of hydroxo complexes of palladium(II) towards nitriles: formation of carboxamide and imino ether derivatives of palladium(II).
J. Ruiz, N. Cutillas, V. Rodríguez, J. Sampedro, G. López, P.A. Chaloner y P.B. Hitchcock. J. Chem. Soc., Dalton Transactions, 1999, 2939-2946
New aryloxo allylpalladium complexes.
J. Ruiz, J.M. Martí, F. Florenciano, G. López. Polyhedron, 1999, 18, 2281-2285
Organometallic diaqua complexes of palladium(II).
J. Ruiz, F. Florenciano, C. Vicente, M.C. Ramírez de Arellano, G. López. Inorganic Chemistry Communications, 2000, 3, 73-75
New di- and trinuclear complexes with pyrazolato bridges. Crystal structures of [{(C6F5)2Pd(μ-pz)(μ-Cl)}2Pd]2- and [(C6F5)2Pd(μ-pz)2Pd(η3-C4H7)] (pz = pyrazolate)
J. Ruiz, F. Florenciano, M.A. Sánchez, G. López, M.C. Ramírez de Arellano, J. Pérez. European Journal of Inorganic Chemistry, 2000, 943-949
Synthesis and characterization of heterodinuclear thiolate complexes containing the Pd(η3-allyl)+ moiety. Crystal structure of [(dppe)Pd(μ-SC6H4Me-p)2Pd(η3-C3H5)][ClO4].
J. Ruiz, J. Giner, V. Rodríguez, G. López, J. Casabó, E. Molins y C. Miravitlles. Polyhedron, 2000, 19, 1624-1631
First complex containing a Pd2(μ2-N=CPh2)2 functional group.
J. Ruiz, V. Rodríguez, N. Cutillas, F. Florenciano, J. Pérez y G. López. Inorganic Chemistry Communications, 2001, 4, 23-25
Synthesis and characterization of chelate and bridging triazenide complexes of palladium and platinum. Stereoselective oxidative addition of chlorine or iodine to [NBu4][Pt(C6F5)2(h2-PhNNNPh)]
J. Ruiz, J. F. J. López, V. Rodríguez, J. Pérez, M.C. Ramírez de Arellano y G. López. J. Chem. Soc., Dalton Transaction, 2001, 2683-2689
Synthesis of terminal and bridging acetonyl complexes of palladium(II). Crystal structures of [{(AsPh3)(C6F5)Pd}2{μ-CH2C(O)CH3}2],
[(AsPh3)(C6F5)Pd{CH2C(O)CH3}(t-BuNC)] and [(o-C6H4CH2NMe2)Pd{O,O'-CH(CO2Et)2}]
J. Ruiz, V. Rodríguez, N. Cutillas, M. Pardo, J. Pérez, G. López, P. A. Chaloner y P. B. Hitchcock. Organometallics, 2001, 20, 1973-1982 Esquema
Synthesis and reactivity of bridging and terminal hydrosulfide palladium and platinum complexes. Crystal structures of [NBu4] [{Pt(C6F5)2(μ-SH)}2], [Pt(C6F5)2(PPh3){S(H)AgPPh3}] and [Pt(C6F5)2(PPh3){S(AuPPh3)2}]
J. Ruiz, V. Rodríguez, C. Vicente,J. M. Martí, G. López y J. Pérez. Inorganic Chemistry, 2001, 40, 5354-5360 Esquema
New dimetallic palladium and platinum complexes containing the tetrakis-(1-pyrazolyl)borate ligand - Crystal structures of [{(C6F5)2Pd}2(m-pz)2B(m-pz)2]-, [{(C6F5)(t-BuNC)Pd}2(m-pz)2B(m-pz)2]+ and [{(C6F5)2Pd(m-pz)2B(m-pz)2Pd(h3-C4H7)]
J. Ruiz, F. Florenciano, V. Rodríguez, C. De Haro, G. López y J. Pérez. European Journal of Inorganic Chemistry, 2002, 2736-2743
Acetimine and 2-methyl-2-amino-4-iminopentane complexes of palladium(II)
J. Ruiz, V. Rodríguez, N. Cutillas, G. López y J. Pérez. Organometallics, 2002, 21, 4912-4918 Esquema
Ureato(1-/) complexes of palladium (II) and platinum (II). Crystal structure of [NBu4][(C6F5)2Pt{PhNC(O)NPri2}]
José Ruiz, Venancio Rodríguez, Consuelo Vicente, José Pérez , Gregorio López, Penny A. Chaloner, Peter B. Hitchcock. Inorganica Chimica Acta, 2003, 351, 114-118
Insertion Reactions into Pd-O and Pd-N Bonds: Preparation of Alkoxycarbonyl, Carbonato, Carbamato, Thiocarbamate, and Thioureide Complexes of Palladium(II)
José Ruiz, Mª Teresa Martínez, Félix Florenciano, Venancio Rodríguez y G. López. Inorganic Chemistry, 2003, 42, 3650-3661 Esquema
Insertion reactions of SO2 into Pd OR bonds: preparation of alkyl sulfito complexes of palladium(II)
J. Ruiz, M. T. Martinez, F. Florenciano, V. Rodriguez, G. Lopez, J. Perez, P. A. Chaloner, P. B. Hitchcock. J. Chem. Soc., Dalton Trans., 2004, 929-932.
Synthesis and characterization of new sulfide aggregates of the type [{Pt2(μ3-S)2(P-P)2}M(C6F5)2] (M=Ni, Pd, Pt; P-P=2PPh3, 2PMe2Ph, dppf)
J. Ruiz, V. Rodríguez, A. Pérez, G. López y D. Bautista. Journal of Organometallic Chemistry, 2004, 689, 12, 2080-2086
Synthesis and characterization of monomeric siloxo palladium(II) complexes: crystal structure of [Pd(tmeda)(C6F5)(OSiPh3)]
J. Ruiz, C. Vicente, V. Rodríguez, N. Cutillas, G. López y C. Ramírez de Arellano. Journal of Organometallic Chemistry, 2004, 689, 11, 1872-1875
New thiocarbamate and thioureate palladium and platinum complexes: synthesis and use as metalloligands. Unprecedented coordination of the thioureate ligand in [(C6F5)2Pd{μ2,η2-SC(NMe2)NPh}Pd(C6F5)(bpzm)]
J. Ruiz, V. Rodríguez, C. De Haro, J. Perez y G. López. Inorganica Chimica Acta, 2004, 357, 2331-2338
Condensation Reactions of Monomeric Hydroxo Palladium Complexes with Active Methyl and Methylene Compounds
J. Ruiz, M.Teresa Martínez, V. Rodríguez, G. López, J. Pérez, P. A. Chaloner y P. B. Hitchcock. J. Chem. Soc., Dalton Trans., 2004, 3521-3527.
Pentafluorophenyl imidato palladium(II) complexes: catalysts for Suzuki cross-coupling reactions
J. Ruiz, C. Vicente, N. Cutillas y J. Pérez. J. Chem. Soc., Dalton Trans., 2005, 1999-2006
New Palladium(II) and Platinum(II) Complexes with the Model Nucleobase 1-Methylcytosine. Antitumour Activity and Interactions with DNA.
J. Ruiz, N. Cutillas, C. Vicente, M. D. Villa, G. López, J. Lorenzo, F. X. Avilés, V. Moreno y D. Bautista. Inorg. Chem., 2005, 44, 7365-7376
Synthesis and Characterization of Heterotrinuclear Complexes of Nickel and Palladium with Pyridinecarboxylate as Bridging Ligands.
J. Ruiz, M. D. Santana, A. Lozano, C. Vicente, G. García, G. López, J. Pérez y L. García. Eur. J. Inorg. Chem., 2005, 3049-3056
Synthesis and Characterization of Monomeric Aryloxo Palladium Complexes of the Type [Pd(N-N)(OAr)(C6F5)]. Crystal structure of [Pd(tmeda)(C6F5)(OC6H4NO2-p)]
J. Ruiz , M. T. Martínez , C. Vicente, V. Rodríguez, G. López , J. Pérez, P. A. Chaloner y P. B. Hitchcock. Z. Anorg. Allg. Chem., 2005, 631, 2227-2231
Palladium(II) and Platinum(II) Organometallic Complexes with the Model Nucleobase Anions of Thymine, Uracil, and Cytosine. Antitumour Activity and Interactions with DNA of the Platinum Compounds.
J. Ruiz, J. Lorenzo, L. Sanglas, N. Cutillas, C. Vicente, M. D. Villa, F. X. Avilés, G. López, V. Moreno, J. Pérez y D. Bautista. Inorg. Chem., 2006, 45, 6347-6360
Can a single C-H×××F hydrogen bond make a difference? Assessing the H×××F bond strength from 2-D 1H-19F CP/MAS NMR
G. Althoff, J. Ruiz, V. Rodríguez,, G. López, J. Pérez y C. Janiak. Cryst. Eng. Comm., 2006, 8, 662-665
A Copper- and Amine-free Sonogashira Reaction of Aryl Halides Catalyzed by 1,3,5-Triaza-7-phosphaadamantane (PTA) Palladium Systems
J. Ruiz, N. Cutillas, F. López, G. López y D. Bautista. Organometallics, 2006, 25, 5768-5773.
A Novel Metal-Binding Mode of Thymine Ncleobases: N(3) and O(4) Chelation
J. Ruiz, María Dolores Villa, Venancio rodríguez, Natalia Cutillas, Consuelo Vicente, G. López and Delia Bautista. Inorg. Chem., 2007, 46, 5448-5449
Palladium(II) and Platinum(II) Organometallic Complexes with 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine. Antitumor Activity of the Platinum Compounds.
J. Ruiz, M.D. Villa, N. Cutillas, G. López, C. de Haro, D. Bautista, V. Moreno y L. Valencia. Inorg. Chem., 2008, 47, 4490-4505.
New Palladium(II) and Platinum(II) Complexes with 9-Aminoacridine: Structures, Luminiscence, Theoretical Calculations and Antitumor Activity.
José Ruiz, Julia Lorenzo, Consuelo Vicente, Gregorio López, José María López de Luzuriaga, Miguel Monge, Francesc X. Avilés, Delia Bautista, Virtudes Moreno y Antonio Laguna. Inorg. Chem., 2008, 47, 6990-7001. Abstract
Crystal structure - solid-state CPMAS 13C NMR correlation in palladacycle pseudo-polymorphs and a vanishing polymorph.
José Ruiz, Venancio Rodríguez, Natalia Cutillas, Anke Hoffmann, Anne-Christine Chamayou, Karolina Kazmierczak y Christoph Janiak. Cryst. Eng. Comm., 2006 (en prensa).
Acetonimine and 4-Imino-2-methylpentan-2-amino Platinum(II) Complexes: Synthesis and in Vitro Antitumor Activity .
José Ruiz, Venancio Rodríguez, Natalia Cutillas, Gregorio López y Delia Bautista. Inorg. Chem., 2008
A novel ruthenium(II) arene based intercalator with potent anticancer activity .
J. Ruiz, Consuelo Vicente, C. de Haro y D. Bautista. Dalton Trans., 2009, 5071-5073. DOI: 10.1039/b907296a.
N1-Coordination in New Palladium(II) and Platinum(II) Complexes with
the Model Nucleobase 9-methylhypoxanthine: First Crystal Structure and Theoretical Calculations.
José Ruiz, Natalia Cutillas, María Dolores Villa, Gregorio López, Arturo Espinosa y Delia Bautista. Dalton Trans., 2009,9637-9644. DOI: 10.1039/b915427b.
New 7-azaindole palladium and platinum complexes: crystal structures and
theoretical calculations. In vitro anticancer activity of the platinum
compounds.
José Ruiz, Venancio Rodríguez, Concepción de Haro, Arturo Espinosa, José Pérez y Christoph Janiak. Dalton Trans., 2010, 39, 3290-3301. DOI: 10.1039/b920854b.
Palladium(II) complexes with pentafluorophenyl ligands: structures, C6F5
fluxionality by 2D-NMR studies and pre-catalysts for the vinyl addition
polymerization of norbornene.
Frederik Blank, Harald Scherer, José Ruiz, Venancio Rodríguez y Christoph Janiak. Dalton Trans., 2010, 39, 3609-3619. DOI: 10.1039/b925674a.
Novel C,N-chelate platinum(II) antitumor complexes bearing a lipophilic
ethisterone pendant.
José Ruiz, Venancio Rodríguez, Natalia Cutillas, Arturo Espinosa y Michael J. Hannon. Journal of Inorganic Biochemistry, 2011, 105, 525-531. DOI: 10.1016/j.jinorgbio.2010.12.005.
Synthesis and Antiproliferative Activity of a C,N-Cycloplatinated(II)
Complex with a Potentially Intercalative Anthraquinone Pendant.
José Ruiz, Consuelo Vicente, Concepción de Haro y Arturo Espinosa. Inorg. Chem. 2011, 50, 2151–2158. DOI: dx.doi.org/10.1021/ic101526h.
η5-Cyclopentadienylpalladium(II) complexes: Synthesis, characterization and use
for the vinyl addition polymerization of norbornene and the copolymerization
with 5-vinyl-2-norbornene or 5-ethylidene-2-norbornene.
Frederik Blank, Jana K. Vieth, José Ruiz, Venancio Rodríguez y Christoph Janiak. Journal of Organometallic Chemistry, 2011, 696, 473-487. DOI: 10.1016/j.jorganchem.2010.08.050.
A potent ruthenium(II) antitumor complex bearing a lipophilic levonorgestrel group. Ruiz José, Rodríguez Venancio, Cutillas Natalia, Espinosa Arturo, Hannon Michael J. Inorg. Chem. 2011; 50(18): 9164-71. DOI: 10.1021/ic201388n
TopNovel C,N-chelate rhodium(III) and iridium(III) antitumor complexes incorporating a lipophilic steroidal conjugate and their interaction with DNA. José Ruiz, Venancio Rodríguez, Natalia Cutillas, Katia G. Samper, Mercè Capdevila , Òscar Palacios and Arturo Espinosa. Dalton Trans., 2012, 41, 12847-12856. DOI: 10.1039/c2dt31654d
Studying the interactions of a platinum(II) 9-aminoacridine complex with proteins and oligonucleotides by ESI-TOF MS. Samper Katia G, Vicente Consuelo, Rodríguez Venancio, Atrian Sílvia, Cutillas Natalia, Capdevila Mercè, Ruiz José, Palacios Òscar. Dalton Trans. 2012; 41(1): 300-6. DOI: 10.1039/C1DT11506E
Novel Bis-C,N-Cyclometalated Iridium(III) Thiosemicarbazide Antitumor Complexes: Interactions with Human Serum Albumin and DNA, and Inhibition of Cathepsin B. José Ruiz, Consuelo Vicente, Concepción de Haro and Delia Bautista. Inorg. Chem. 2013, 52, 974-982. DOI: 10.1021/ic302219v
TopNovel C,N-chelate rhodium(III) and iridium(III) antitumor complexes incorporating a lipophilic steroidal conjugate and their interaction with DNA. José Ruiz, Venancio Rodríguez, Natalia Cutillas, Katia G. Samper, Mercè Capdevila , Òscar Palacios and Arturo Espinosa. Dalton Trans., 2012, 41, 12847-12856. DOI: 10.1039/c2dt31654d
Anticancer cyclometalated complexes of platinum group metals and gold. Natalia Cutillas, Gorakh S. Yellol, Concepción de Haro, Consuelo Vicente, Venancio Rodríguez, José Ruiz. Coordination Chemistry Reviews. 2013, 257, 19–20, 2784–2797. DOI: 10.1016/j.ccr.2013.03.024
New steroidal 7-azaindole platinum(II) antitumor complexes. Ana Zamora, Venancio Rodríguez, Natalia Cutillas, Gorakh S. Yellol, Arturo Espinosa, Katia G. Samper, Mercè Capdevila, Òscar Palacios, José Ruiz. Journal of Inorganic Biochemistry. 2013, 128, 48–56 DOI: 10.1016/j.jinorgbio.2013.07.010
On the antitumor properties of novel cyclometalated benzimidazole Ru(II), Ir(III) and Rh(III) complexes. Gorakh S. Yellol, Antonio Donaire, Jyoti G. Yellol, Vera Vasylyeva, Christoph Janiak and José Ruiz. Chem. Commun., 2013, 49, 11533-11535. DOI: 10.1039/C3CC46239K
Anticancer C,N-Cycloplatinated(II) Complexes Containing Fluorinated Phosphine Ligands: Synthesis, Structural Characterization, and Biological Activity. Cutillas N, Martínez A, Yellol GS, Rodríguez V, Zamora A, Pedreño M, Donaire A, Janiak C, Ruiz J. Inorg Chem. 2013, 52(23), 13529-35. DOI: 10.1021/ic401973k.
TopUnderstanding the interaction of an antitumoral platinum(II) 7-azaindolate complex with proteins and DNA. Katia G Samper, Venancio Rodríguez, Elisabeth Ortega-Carrasco, Sílvia Atrian, Jean Didier Maréchal, Natalia Cutillas, Ana Zamora, Concepción de Haro, Mercè Capdevila, José Ruiz, Oscar Palacios. Biometals, 27, 6, 1159-1177, 2014. DOI 10.1007/s10534-014-9780-1
TopSynthesis of 2-Pyridyl-benzimidazole Iridium(III), Ruthenium(II), and Platinum(II) Complexes. Study of the Activity as Inhibitors of Amyloid-ß Aggregation and Neurotoxicity Evaluation. Gorakh S. Yellol, Jyoti G. Yellol, Vijaya B. Kenche, Xiang Ming Liu, Kevin J. Barnham, Antonio Donaire, Christoph Janiak, and Jose Ruiz. Inorg. Chem. 2015, Vol. 54, 470-475. DOI: 10.1021/ic502119b
On the Dual Antitumor and Anti-angiogenic Activity of Organoplatinum(II) Complexes. Ana Zamora, Sergio A. Pérez, Venancio Rodríguez, Christoph Janiak, Gorakh S. Yellol, and José Ruiz. J. Med. Chem. 2015, Vol. 58, 1320-1336. DOI: 10.1021/jm501662b
Crystal structure, theoretical calculations and antimicrobial properties of [Pt(tetramethylthiourea)4] [Pt(CN)4] 4H2O. Haseeba Sadaf, Anvarhusein A. Isab, Saeed Ahmad, Arturo Espinosa, Míriam Mas-Montoya, Islam Ullah Khan, Ejaz, Seerat-ur Rehman, Muhammad Akhtar Javed Ali, Muhammad Saleem, José Ruiz, Christoph Janiak. J. Molecular Structure, 2015, Vol. 1085, 155-161. DOI: 10.1016/j.molstruc.2014.12.076
Antitumor Properties of Platinum(IV) Prodrug-Loaded Silk Fibroin Nanoparticles. A. Abel Lozano-Pérez, Ana L. Gil, Sergio A. Pérez,b Natalia Cutillas, Hajo Meyer, Mónica Pedreño, Salvador Aznar-Cervantes, Christoph Janiak, Jose Luis Cenis, and José Ruiz. Dalton Trans. 2015, Vol. 44, 13513-13521. DOI: 10.1039/C5DT00378D
In Vitro Characterization of a Novel C,N-cyclometalated Benzimidazole Ru(II) Arene Complex: Stability, Intracellular Distribution and Binding, Effect on Organic Osmolyte Homeostasis and Induction of Apoptosis. Celina Støving Dam, Sergio Alejo Perez Henarejos, Theodosia Tsolakou, Christian Alexander Segato, Bente Gammelgaard, Gorakh S. Yellol, José Ruiz, Ian Henry Lambert, Stefan Stürup. Metallomics, 2015, Vol. 7, 885-895. DOI: 10.1039/c5mt00056d
Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure-Activity Relationship Study. Yellol J, Pérez SA, Buceta A, Yellol G, Donaire A, Szumlas P, Bednarski PJ, Makhloufi G, Janiak C, Espinosa A, Ruiz J. J Med Chem. 2015, 58, 7310-7327. DOI: 10.1021/acs.jmedchem.5b01194
TopHighly potent extranuclear-targeted luminescent iridium(iii) antitumor agents containing benzimidazole-based ligands with a handle for functionalization. J. Yellol, S. A. Pérez, G. Yellol, J. Zajac, A. Donaire, G. Vigueras, V. Novohradsky, C. Janiak, V. Brabec, J. Ruiz, Chem. Commun., 2016, 52, 14165 - 14168. DOI: 10.1039/c6cc07909a
Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2]. E. Wachter, A. Zamora, L. Nease, D. K. Heidary, J. Ruiz and E. C. Glazer, Chem. Comm., 2016, 52, 10121-10124. DOI: 10.1039/c6cc04813g
TopRuthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage. Ana Zamora, Catherine A. Denning, David K. Heidary, Erin Wachter, Leona A. Nease, José Ruiz y Edith C. Glazer. Dalton Trans. 2017, 46, 2165-2173. DOI: 10.1039/C6DT04405K
Exploring the Influence of the Aromaticity on the Anticancer and Antivascular Activities of Organoplatinum(II) Complexes. Zamora A, Pérez S.A, Rothemund M, Rodríguez V, Schobert R, Janiak C, Ruiz J. Chemistry. Eur J. 2017, 23:5614-5625. DOI: 10.1002/chem.201700717.
Somatostatin receptor-targeted organometallic iridium(III) complexes as novel theranostic agents. Novohradsky V, Zamora A, Gandioso A, Brabec V, Ruiz J, Marchán V. Chem. Commun. 2017, 53:5523-5526. DOI: 10.1039/c7cc01946g.
New Acridine Thiourea Gold(I) Anticancer Agents: Targeting the Nucleus and Inhibiting Vasculogenic Mimicry. Pérez S.A, de Haro C, Vicente C, Donaire A, Zamora A, Zajac J, Kostrhunova H, Brabec V, Bautista D, Ruiz J. ACS Chem Biol. 2017. DOI: 10.1021/acschembio.7b00090.
DFT Simulation of Structural and Optical Properties of 9-Aminoacridine Half-Sandwich Ru(II), Rh(III) and Ir(III) Antitumoural Complexes and their Interaction with DNA. José Pedro Cerón-Carrasco, José Ruiz, Consuelo Vicente, Concepción de Haro, Delia Bautista, José Zúñiga, Alberto Requena. J. Chem. Theory Comput. 2017, 13, 3898–3910. DOI: 10.1021/acs.jctc.7b00139
Organoruthenium Complexes with C^N Ligands are Highly Potent Cytotoxic Agents that Act by a New Mechanism of Action. Vojtech Novohradsky, Jyoti Yellol, Olga Stuchlikova, María Dolores Santana, Hana Kostrhunova, Gorakh Yellol, Jana Kasparkova, Delia Bautista, Jose Ruiz, Viktor Brabec. Chem. Eur. J. 2017, 23, 15294-15299. DOI: 10.1002/chem.201703581
TopA new c,n-cyclometalated osmium(ii) arene anticancer scaffold with a handle for functionalization and antioxidative properties. Ortega Forte E., Yellol J.G., Rothemund M., Ballester Hernández F.J., Rodríguez Hernández V., Yellol G.., Janiak C., Schobert R., Ruiz López J. Chem Commun, 2018, 54, 11120—11123. DOI: 10.1039/C8CC06427J
Toward Angiogenesis Inhibitors Based on the Conjugation of Organometallic Platinum(II) Complexes to RGD Peptides. Dr. Ana Zamora, Albert Gandioso, Dr. Anna Massaguer, Dr. Silvia Buenestado, Dr. Carme Calvis, Dr. Jose Luis Hernández, Dr. Francesc Mitjans, Dr. Venancio Rodríguez, Prof. José Ruiz, Dr. Vicente Marchán. Chem. Med. Chem. 2018, 13, 17, 1741-1741. DOI: 10.1002/cmdc.201800570
Exploring the Effect of the Polypyridyl Ligands on Anticancer Activity of Phosphorescent Iridium(III) Complexes: From Proteosynthesis Inhibitors to Photodynamic Therapy Agents, Jitka Pracharova, Gloria Vigueras, Vojtech Novohradsky, Natalia Cutillas, Christoph Janiak, Hana Kostrhunova, Jana Kasparkova, José Ruiz, and Viktor Brabec. Chem. Eur. J. 2018. DOI: 10.1002/chem.201705362
Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy, Ana Zamora, Gloria Vigueras, Venancio Rodríguez, M. Dolores Santana, José Ruiz. Coord. Chem. Rev. 2018, 360, 34-76. DOI: 10.1016/j.ccr.2018.01.010
TopMolecular superoxide radical photogeneration in cancer cells by dipyridophenazine iridium(III) complexes. Novohradsky, Vojtech; Vigueras, Gloria; Pracharova, Jitka; Cutillas, Natalia; Janiak, Christoph; Kostrhunova, Hana; Brabec, Viktor; Ruiz, Jose; Kasparkova, Jana. Inorganic Chemistry Frontiers, 2019, 6 (9), 2500-2513. DOI: 10.1039/c9qi00811j
Luminescent Gold(I) Complexes of 1-Pyridyl-3-anthracenylchalcone Inducing Apoptosis in Colon Carcinoma Cells and Antivascular Effects. González JJ, Ortega E, Rothemund M, Gold M, Vicente C, de Haro C, Bautista D, Schobert R, Ruiz J. Inorg Chem. 2019, 58 (19), 12954-12963. DOI: 10.1021/acs.inorgchem.9b01901
New half-sandwich ruthenium(ii) complexes as proteosynthesis inhibitors in cancer cells. Francisco J. Ballester, Enrique Ortega, Vanesa Porto, Hana Kostrhunova, Nerea Davila-Ferreira, Delia Bautista, Viktor Brabec, Fernando Domínguez, M. Dolores Santana and José Ruiz. Chem. Commun., 2019, 55, 1140-1143. DOI: 10.1039/C8CC09211G
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated IrIII Complex Conjugated to a Far‐Red Emitting Coumarin. Dr. Vojtech Novohradsky, Anna Rovira, Cormac Hally, Alex Galindo, Gloria Vigueras, Dr. Albert Gandioso, Marie Svitelova, Dr. Roger Bresolí-Obach, Dr. Hana Kostrhunova, Dr. Lenka Markova, Dr. Jana Kasparkova, Prof. Santi Nonell, Prof. José Ruiz, Prof. Viktor Brabec, Dr. Vicente Marchán Angewandte International Edition Chemie, 2019, 58, 19, 6311-6315. DOI: 10.1002/anie.201901268
TopAn Erlotinib gold(I) conjugate for combating triple-negative breast cancer. Enrique Ortega, Ana Zamora, Uttara Basu, Petra Lippmann, Venancio Rodríguez, Christoph Janiak, Ingo Ott, José Ruiz. Journal of Inorganic Biochemistry 203 (2020) 110910. DOI: 10.1016/j.jinorgbio.2019.110910
Ru(II) photosensitizers competent for hypoxic cancers via green light activation. Francisco J. Ballester, Enrique Ortega, Delia Bautista, M. Dolores Santana and José Ruiz. Coord. Chem. Commun., 2020, 56, 10301. DOI: 10.1039/D0CC02417A
Amino-Functionalized Mesoporous Silica Nanoparticle-Encapsulated Octahedral Organoruthenium Complex as an Efficient Platform for Combatting Cancer. Marina Martínez-Carmona,Quy P. Ho, Je´re´my Morand, Ana García, Enrique Ortega, Luiza C. S. Erthal, Eduardo Ruiz-Hernandez, M. Dolores Santana, Jose´ Ruiz,Maria Vallet-Regí,and Yurii K. Gun’ko. Inorg. Chem. 2020, 59, 10275-10284. DOI: 10.1021/acs.inorgchem.0c01436
TopNovel organo-osmium(ii) proteosynthesis inhibitors active against human ovarian cancer cells reduce gonad tumor growth in Caenorhabditis elegans. Enrique Ortega, Francisco J. Ballester, Alba Hernández-García, Samanta Hernández-García, M. Alejandra Guerrero-Rubio, Delia Bautista, M. Dolores Santana, Fernando Gandía-Herrero and José Ruiz. Inorg. Chem. Front., 2021, 8, 141-155. DOI: 10.1039/C9QI01704F
A 2-(benzothiazol-2-yl)-phenolato platinum(II) complex as potential photosensitizer for combating bacterial infections in lung cancer chemotherapy. Enrique Ortega, Cristina Pérez-Arnaiz, Venancio Rodríguez, Christoph Janiak, Natalia Busto, Begoña García and José Ruiz. European Journal of Medicinal Chemistry, 222, 113600 (2021). DOI: 10.1016/j.ejmech.2021.113600
A Cyclometalated Ir(III) Complex Conjugated to a Coumarin Derivative Is a Potent Photodynamic Agent against Prostate Differentiated and Tumorigenic Cancer Stem Cells. Dr. Vojtech Novohradsky, Dr. Lenka Markova, Dr. Hana Kostrhunova, Prof.Dr. Jana Kasparkova, Prof. José Ruiz, Prof. Vicente Marchán, Prof.Dr. Viktor Brabec. Chemistry – A European Journal, 27, 33, 8547-8556 (2021). DOI: 10.1002/chem.202100568
Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences. Ana Zamora, Erin Wachter, María Vera, David K. Heidary, Venancio Rodríguez, Enrique Ortega, Vanesa Fernández-Espín, Christoph Janiak, Edith C. Glazer, Giampaolo Barone and José Ruiz. Inorg. Chem. 60, 4, 2178–2187 (2021). DOI: 10.1021/acs.inorgchem.0c02648
Targeting translation: a promising strategy for anticancer metallodrugs. Enrique Ortega, Gloria Vigueras, Francisco José Ballester and José Ruiz. Coordination Chemistry Reviews, 446, 214129 (2021). DOI: 10.1016/j.ccr.2021.214129
A photoactivated Ir(iii) complex targets cancer stem cells and induces secretion of damage-associated molecular patterns in melanoma cells characteristic of immunogenic cell death. Gloria Vigueras, Lenka Markova, Vojtech Novohradsky, Alicia Marco, Natalia Cutillas, Hana Kostrhunova, Jana Kasparkova, José Ruiz and Viktor Brabec. Inorg. Chem. Front. 8(21), 4696–4711 (2021). DOI: https://doi.org/10.1039/D1QI00856K
COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer Agents. Enrique Ortega-Forte, Anna Rovira, Albert Gandioso, Joaquín Bonelli, Manel Bosch, José Ruiz, and Vicente Marchán. J. Med. Chem. 64, 23, 17209–17220 (2021). DOI: 10.1021/acs.jmedchem.1c01254
TopPolyurethane–polyurea hybrid nanocapsules as efficient delivery systems of anticancer Ir(III) metallodrugs. Joaquín Bonelli, Enrique Ortega-Forte, Gloria Vigueras, Manel Bosch, Natalia Cutillas, Josep Rocas, José Ruiz and Vicente Marchán. Inorg. Chem. Front., 2022, 9, 2123. DOI: 10.1039/D1QI01542G
Dipyridophenazine iridium(III) complex as a phototoxic cancer stem cell selective, mitochondria targeting agent. Lenka Markova, Vojtech Novohradsky, Jana Kasparkova, José Ruiz, Viktor Brabec. Chemico-Biological Interactions, 360, 109955 (2022). DOI: 10.1016/j.cbi.2022.109955
Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane–Polyurea Hybrid Nanocarrier. Joaquín Bonelli, Enrique Ortega-Forte, Anna Rovira, Manel Bosch, Oriol Torres, Cristina Cuscó, Josep Rocas, José Ruiz and Vicente Marchán. Biomacromolecules, 23, 7, 2900–2913 (2022). DOI: 10.1021/acs.biomac.2c00361
Inert Cationic Iridium(III) Complexes with Phenanthroline-based Ligands: Application in Antimicrobial Inactivation of Multidrug-Resistant Bacterial Strains. Natalia Busto, Gloria Vigueras, Natalia Cutillas, Begoña García and José Ruiz. Dalton Trans. 51, 9653-9663 (2022). DOI: 10.1039/D2DT00752E
Potent anticancer activity of a novel iridium metallodrug via oncosis. Enrique Ortega-Forte, Samanta Hernández-García, Gloria Vigueras, Paula Henarejos-Escudero, Natalia Cutillas, José Ruiz & Fernando Gandía-Herrero. Cellular and Molecular Life Sciences volume 79, 510 (2022). DOI: 10.1007/s00018-022-04526-5
TopA near-infrared light-activatable Ru(<scp>ii</scp>)-coumarin photosensitizer active under hypoxic conditions. Enrique Ortega-Forte, Anna Rovira, Marta López-Corrales, Alba Hernández-García, Francisco José Ballester, Eduardo Izquierdo-García, Mireia Jordà-Redondo, Manel Bosch, Santi Nonell, María Dolores Santana, José Ruiz, Vicente Marchán and Gilles Gasser. Chem. Sci. 14, 7170-7184 (2023). DOI: 10.1039/D3SC01844J
Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria. Alicia Marco, Gloria Vigueras, Natalia Busto, Natalia Cutillas, Delia Bautista and José Ruiz. Dalton Trans. 52, 13482-13486 (2023). DOI:10.1039/D3DT01678A
Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells. Vojtech Novohradsky, Alicia Marco, Lenka Markova, Natalia Cutillas, José Ruiz and Viktor Brabec. J. Med. Chem. 66, 14, 9766–9783 (2023). DOI: 10.1021/acs.jmedchem.3c00586
Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates. Anna Rovira, Martí i Franquès, Enrique Ortega-Forte, Cormac Hally, Mireia Jordà-Redondo, Diego Abad-Montero, Gloria Vigueras, Jesús I. Martínez, Manel Bosch, Santi Nonell, José Ruiz and Vicente Marchán. J. Med. Chem. 66, 12, 7849–7867 (2023). DOI: 10.1021/acs.jmedchem.3c00189
Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis. Alba Hernández-García, Lenka Marková, María Dolores Santana, Jitka Prachařová, Delia Bautista, Hana Kostrhunová, Vojtěch Novohradský, Viktor Brabec, José Ruiz and Jana Kašpárková. Inorg. Chem. 62, 16, 6474–6487 (2023). DOI: 10.1021/acs.inorgchem.3c00501
Newly synthesized benzothiazolyl-1,2,3-triazole derivatives: Intramolecular charge transfer tuning, solvatofluorochromism and antiproliferative properties. F. J. Ballester; E. Ortega-Forte; D. Bautista; M. D. Santana; G. Barone; J. Ruiz. Dyes and Pigments, 209-A, 110905 (2023). DOI: 10.1016/j.dyepig.2022.110905
TopNovel Re(I) Complexes as Potential Selective Theranostic Agents in Cancer Cells and In Vivo in Caenorhabditis elegans Tumoral Strains. Alicia Marco; Pezhman Ashoo; Samanta Hernández-García; Pedro Martínez-Rodríguez; Natalia Cutillas; Annette Vollrath; Dustin Jordan; Christoph Janiak; Fernando Gandía-Herrero; José Ruiz. Journal of Medicinal Chemistry. 67, 10, 7891–7910 (2024). DOI:10.1021/acs.jmedchem.3c01869
New Cyclometalated Ru(II) Polypyridyl Photosensitizers Trigger Oncosis in Cancer Cells by Inducing Damage of Cellular Membranes. Jakub Cervinka; Alba Hernández-García; Delia Bautista; Lenka Marková; Hana Kostrhunova; Jaroslav Malina; Jana Kasparkova; M. Dolores Santana; Viktor Brabec; Jose Ruiz. Inorganic Chemistry Frontiers (2024). DOI: 10.1039/d4qi00732h
Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells. Jana Kasparkova; Vojtech Novohradsky; José Ruiz; Viktor Brabec. Chemico-Biological Interactions. 392:110921 (2024). DOI:10.1016/j.cbi.2024.110921
Photoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1,2,3-triazole Chelators for Cancer Treatment. Francisco J. Ballester; Alba Hernández-García; M. Dolores Santana; Delia Bautista; Pezhman Ashoo; Enrique Ortega-Forte; Giampaolo Barone; José Ruiz. Inorganic Chemistry. 63, 14, 6202–6216 (2024). DOI: 10.1021/acs.inorgchem.3c04432
Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis. Jana Kasparkova, Alba Hernández-García, Hana Kostrhunova, Marta Goicuría, Vojtec Novohradsky, Delia Bautista, Lenka Markova, María Dolores Santana, Viktor Brabec and José Ruiz. J. Med. Chem. 67, 1, 691–708 (2024). DOI:10.1021/acs.jmedchem.3c01978
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