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Professor of Biochemistry and Molecular Biology
Department of Biochemistry and Molecular Biology “B” and Immunology.
Faculty of Chemistry.
University of Murcia.
Main Researcher of:
Sustainable Chemistry Group (E-060-10)
Sustainable Chemistry Research Node - CMN
Researcher IDs:
Web of science: E-8606-2011
Scopus: 24725096300
ORCID: 0000-0001-6043-3893
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Merits |
Responsabilidades Institucionales
Decano de la Facultad de Química. Universidad de Murcia (2014-2022).
Vicedecano de Bioquímica. Facultad de Química. Universidad de Murcia, 1996 - 2014
Miembro del Claustro Universidad de Murcia, 2008 - 2014
Presidente de la Conferencia de Responsables de Grados en Bioquímica y Biotecnología de las Universidades españolas, 2008 - 2012
Organización de Congresos y Meetings científicos internacionales
BIOTEC 2017. Congreso Nacional De Biotecnología, Murcia, Spain, 2017
5th International Conference on Green Process Engineering (Gpe 2016), Quebec, Canada, 2016
Int. Advisory Board. 8th Green Solvents Conference - Dechema, Kiel. Germany, 2016
Int. Advisory Board. 7th Green Solvent Conference. Dresden. Germany, 2014
Co-Chairman. 4th Int. Cong. Green Process Engineering GPE 2014. 300 people. Sevilla. Spain, 2014
Int. Advisory Board. 6th Green Solvent Conference. 200 people. Boppard. Germany, 2012
Int. Advisory Board. 3th Int. Cong. Green Process Eng. GPE 2011. 200 people. Malaysia, 2011
Int. Advisory Board. 5th Green Solvent Conference. 200 people. Berchtesgaden Germany, 2010
Int. Advisory Board. 2th Int. Cong. Green Process Engineering. GPE2009. 450 p. Venice. Italy, 2009
Pertenencia a comités científicos de Revistas Internacionales / Referee.
Editorial Board, The Scientific World Journal Journal. Hindawi Publising Co. 2012
Editorial Board, Current Green Chemistry – BENTHAM SCIENCE. 2012
Review panel member, ChemSusChem, Wiley VCH. 2010
Senior Reviewer, Green Chemistry. RSC. UK. 2009
Scientific Advisory Board and Research Project Evaluator. Agence Nationale de Recherche (ANR). Chimie Durable Committee (CD2I). Ministry of Science. France. 2009
Referee for the following Elsevier Journals: Appl. Catal. B Environ.; Appl. Energ.; Bioresour. Technol.; Catal. Commun.; Catal. Tod.; Enzyme Microb. Technol.; Int. J. Biol. Macromol.; Biomass Bioenerg.; J. Biotechnol.; Fuel; J. Membr. Sci.; J. Mol. Catal. A Chem.; J. Mol. Catal. B Enzym.; Process Biochem.; Sep. Purif. Technol.; J. Supercrit. Fluids. 2004
Comités editoriales
Bentham Science Publishers ISSN. 2213-3461
The Scientific World Journal ISSN. 1537-744X
The Scientific World Journal ISSN. 1537-744X
Minireviews in Organic Chemistry ISSN. 1570-193X
Miembro de Sociedades Científicas
American Chemical Society (ACS) Member. 2004
European Federation on Biotechnology (EFB) Member. 2001
Spanish Society of Biotechnology (SEBIOT) Member. 1987
Spanish Society of Biochemistry and Molecular Biology (SEBBM) Member. 1986
National Spanish Association of Chemists (ANQUE). Member. 1985
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Research |
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Mi trayectoria científica se encuentra profundamente vinculada a la combinación de biocatalizadores con sistemas ingenieriles para el desarrollo de procesos innovadores, sostenibles y tendentes a su aplicación industrial. Durante los últimos 15 años, algunas de mis contribuciones científicas han podido calificarse de pioneras en el desarrollo de procesos biocatalíticos en solventes neotéricos (ILs y scCO2). |
A destacar tres descubrimientos de gran impacto: i)En 2001, el efecto “superestabilizador” que proporcionan los ILs hidrofóbicos a las enzimas (Biotechnol. Lett. 23, 1529-1533; Biotechnol. Bioeng. 75, 563-569); ii) En 2002 desarrollo de un nuevo concepto de reactor biocatalítico verde y continuo, basado en la combinación de ILs y scCO2 (tal como destacó P. Ball, Editor de Nature, en Nature Science Update 2002), y los desarrollos posteriores con líquidos iónicos soportados (i.e. portada de la revista ChemSusChem en 2012); iii) En 2012, el comportamiento tipo esponja de los ILs basados en largas cadenas alifáticas, que permite desarrollar procesos integrados y sostenibles de transformación y separación de productos mediante procedimientos sencillos, tal como destacó S.R. Ritter, Editor de Chemical & Engineering News, y fue portada de la revista Green Chem. La aplicación de esta estrategia a la transformación de un aceite modelo (trioleina) en biodiesel fue objeto de publicación en Energ. Environm. Sci en 2013. Toda esta experiencia acumulada nos ha situado en una posición privilegiada para el desarrollo de procesos químicos limpios y sostenibles de aplicación industrial, y susceptibles de patente (i.e. transformación integral de aceites no comestibles en biocarburantes, etc.).
Ver entrevista en Green Chemistry Blog: Meet our authors (Royal Society of Chemistry – UK):
http://blogs.rsc.org/gc/2012/04/23/meet-our-authors-pedro-lozano/
Investigador Principal en Proyectos de Investigación.
2019 - 2022. Procesos (bio)Catalíticos Sostenibles en Líquidos Iónicos y su Aplicación a la Industria Cosmética y Farmacéutica. SENECA CARM. Ref. 20790/PI/18.
2019 - 2021. Nuevos procesos multi-catalíticos verdes basados en la tecnología de los líquidos iónicos: Desde las materias primas sencillas hasta los químicos con valor añadido. MICINN. Ref. RTI2018-098233-B-C21.
2016 - 2019. Procesos Quimio-Enzimáticos Sostenibles de Interés Industrial en Líquidos Iónicos Tipo Esponja y Fluidos Supercríticos. MINECO/FEDER. Ref. CTQ-2015-67927-R.
2015 - 2018. Procesos Quimio-Enzimáticos Basados en la Química Verde: Aplicaciones para la obtención de biocombustibles de 2ª Generación y la volorización del Glicerol. FUNDACION SENECA. Ref. 19278/PI/14.
2012 - 2014. Procesos Quimio-Enzimáticos Continuos Mediante Tecnologías Sostenibles ( Líquidos Iónicos, Fluidos Supercríticos y Microondas). MINISTERIO DE CIENCIA E INNOVACIÓNC. Ref. CTQ2011-28903-C02-02.
2009 - 2013. Tecnología enzimática para la obtención de biocombustibles en disolventes verdes. Fundación Séneca. Gobierno de la Región de Murcia. Ref.: 08616/PI/08.
2009 - 2011. Tecnología enzimática en solventes verdes no acuosos para la obtención de biocombustibles. MICINN Ref. CTQ2008-00877/PPQ.
2007 - 2008. Obtención de ésteres bioactivos mediante catálisis enzimática en sistemas no acuosos. Consejería de Industria. Gobierno de la Región de Murcia. Ref.: BIO-BMC 06/01-0002.
2006 - 2008. Desarrollo de tecnologías enzimáticas para procesos químicos en líquidos iónicos de función específica y fluidos supercríticos. Fundación Séneca. Gobierno de la Región de Murcia. Ref.: 02910/PI/05.
2005 - 2008. Tecnología enzimática para procesos químicos en líquidos iónicos de función específica y fluidos supercríticos. MICINN. Ref CTQ 2005-01571.
2002 - 2005. Procesos biocatalíticos en reactores de membrana con solventes neotéricos (líquidos iónicos y fluidos supercríticos). CICYT. Ref: PPQ2002-03549.
Investigador Principal en Contratos de Investigación con Empresas.
2017. Obtención de compuestos bioactivos de interés para la industria cosmética. TAHE Productos Cosméticos SL – CDTI.
2013 - 2015. Desarrollo de nuevas estrategias de tinción capilar por modificación química de proteínas. TAHE Productos Cosméticos SL – CDTI.
Patentes
Inventors: P. Lozano, T. de Diego, J.L Iborra, M. Vaultier. Title: Use of ionic liquids for implementing a process for the preparation of biodiesel. Patents EP20080291101 20081121; EP20090755915 20091120; WO 2010057996; US 8,470,565 B2.
Inventors: P. Lozano, E. Álvarez, J. M. Bernal, S. Nieto, C. Gómez, A. Donaire. Title: Method for Enzymatic Systhesis of Monoesters of Polyhydroxilated Compounds. Applicants: University of Murcia. ES2735636A1; WO2019243656A1 (December, 26, 2019). Agent: : Mario CARPINTERO LOPEZ (CÓDIGO DE AGENTE: 0953/9) Herrero & Asociados.
E. Alvarez, S. Nieto, A. Donaire, P. Lozano. Síntesis Enzimática de Monoésteres de Pantenol en Sistemas Libres de Disolventes Orgánicos. P201830595.
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Some relevant publications |
Biomacromolecules, 6, 1457-1464 (2005) DOI: 10.1021/bm049259q
Biotechnol. Bioeng., 75, 563-569 (2001) DOI: 10.1002/bit.10089
Biotechnol. Lett., 23, 1529-1533 (2001) DOI: 10.1023/A:1011697609756
Chem. Commun., 7, 692-693 (2002) DOI: 10.1039/B200055E
Biotechnol., Bioeng., 88, 916-924 (2004) DOI: 10.1002/bit.20330
Biotechnol. Prog., 19, 380-382 (2003) DOI: 10.1021/bp025759o
Green Chem., 12, 555-569 (2010) DOI: 10.1039/B919088K
Biotechnol. Prog., 20, 661-669 (2004) DOI: 10.1021/bp0342497
J. Mol Catal. B Enzym., 21, 9-13 (2003) DOI: 10.1016/S1381-1177(02)00128-5
?J. Chromatogr. A, 830, 477-483 (1999) DOI: 10.1016/S0021-9673(98)00938-8
J. Biochem. Bioph. Meth., 43, 367-378 (2000) DOI: 10.1016/S0165-022X(00)00090-7
Adv. Synth. Catal., 349, 1077-1084 (2007) DOI: 10.1002/adsc.200600554
J. Supercrit. Fluids. 29, 121-128 (2004) DOI: 10.1016/S0896-8446(03)00050-0
J. Biotechnol., 140, 234-241 (2009) DOI: 10.1016/j.jbiotec.2009.01.012
J. Biotechnol., 35, 9-18 (1994) DOI: 10.1016/0168-1656(94)90186-4
J. Mol Catal. B: Chem., 214, 113-119 (2004) DOI: 10.1016/j.molcata.2003.09.034
Biotechnol. Lett., 28, 1559-1565 2006) DOI: 10.1007/s10529-006-9130-7
J. Membrane Sci., 201, 55-64 (2002) DOI: 10.1016/S0376-7388(01)00703-7
Biocatal. Biotransf., 23, 169-176 (2005) DOI: 10.1080/10242420500198657
J. Supercrit. Fluids, 40, 93-100 (2007) DOI: 10.1016/j.supflu.2006.03.025
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List of Publications (1987-2020) |
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Villa R., Álvarez E., Nieto S., Donaire A., García-Verdugo E., Luis S.V., Lozano Rodríguez P., Chemo-enzymatic production of omega-3 monoacylglycerides using sponge-like ionic liquids and supercritical carbon dioxide.
Green Chemistry, 22, 5701, 2020. DOI: 10.1039/d0gc02033h |
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Lozano Rodríguez P., Cognet P., Poux M., The green catalytic processes special issue on the 6th International Congress on Green Process Engineering Preface.
Catalysis Today, 346, 1-3, 2020. DOI: 10.1016/j.cattod.2019.11.022 |
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Villa R., Álvarez E., Rodríguez J., Porcar R., García-Verdugo E, Luis S.V., Lozano Rodríguez P. Ionic liquids as an enabling tool to integrate reaction and separation processes, Green Chemistry, 21, 6527-6544, 2019. DOI: 10.1039/c9gc02553g |
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Álvarez E., Rodríguez J., Villa R., Gómez C., Nieto S., Donaire A., Lozano Rodríguez P. Clean Enzymatic Production of Flavor Esters in Spongelike Ionic Liquids, ACS Sustainable Chemistry and Engineering, 7,13307-13314, 2019. DOI: 10.1021/acssuschemeng.9b02537 |
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Lozano Rodríguez P., Álvarez E., Nieto S., Villa R., Bernal J.M., Donaire A. Biocatalytic synthesis of panthenyl monoacyl esters in ionic liquids and deep eutectic solvents. Green Chemistry, 21, 3353, 2019. DOI: 10.1039/c9gc01076a |
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J Pérez, JL Serrano, G Sánchez, P Lozano, I da Silva, A Alcolea. From Coordination Complexes to Potential Heterogeneous Catalysts via Solid-State Thermal Decomposition: Precursor, Atmosphere and Temperature as Tuning Variables. Chemistry Select, 4, 8365-8371, 2019. DOI:10.1002/slct.201901392 |
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Pedro Lozano, Juana M Bernal, Celia Gómez, Elena Álvarez, Bohdana Markiv, Eduardo García-Verdugo, Santiago V Luis. Green biocatalytic synthesis of biodiesel from microalgae in one-pot systems based on sponge-like ionic liquids. Catalysis Today, XXX, 2019. DOI:10.1016/j.cattod.2019.01.073 |
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P Lozano, E Alvarez, S Nieto, R Villa, JM Bernal, A Donaire. Biocatalytic synthesis of panthenyl monoacyl esters in ionic liquids and deep eutectic solvents. Green Chemistry, 21, 3353-3361, 2019. DOI:10.1039/C9GC01076A |
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Porcar R., Nuevo Vialás D., Garcia-Verdugo E., Lozano Rodriguez P., Sanchez-Marcano J., Burguete M.I., Luis Lafuente S.V. New Porous Monolithic Membranes based on Supported Ionic Liquid-Like Phases for Oil/Water Separation and Homogenous Catalyst Immobilisation. Chemical Communications, 54, 2385-2388, 2018. DOI:10.1039/C8CC00371H |
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Lozano Rodriguez P., Gomez Garcia C., Nieto Ceron S., Sanchez Gomez G., Garcia-Verdugo E., Luis S.V. Highly Selective Biocatalytic Synthesis of Monoacylglycerides in Sponge-Like Ionic Liquids. Green Chemistry, 19, 390-396, 2017. DOI:10.1039/C6GC01969B |
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Lozano Rodriguez P., Gómez García C., Nicolas Saavedra A., Polo Campillo R., Nieto Ceron S., Bernal Palazón J.M., Garcia-Verdugo E., Luis Lafuente S.V. Clean enzymatic preparation of Oxygenated Biofuels from Vegetable and Waste Cooking Oils by using Spongelike Ionic Liquids Technology. . Acs Sustainable Chemistry & Engineering, 4, 6125-6132, 2016. DOI:10.1021/Acssuschemeng.6b01570 |
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Lozano Rodriguez P., Garcia-Verdugo E., Luis Lafuente S.V. Ionic Liquids in Continuous Flow Processes. Journal of the American Oil Chemists Society, 27, 28-31, 2016. DOI:10.21748/inform.10.2016.28 |
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Porcar R., Lozano Rodriguez P., Garcia-Verdugo E., Luis Lafuente S.V. Supramolecular interactions based on Ionic Liquids for tuning of the Catalytic Efficiency of (L)-Proline. Acs Sustainable Chemistry & Engineering, 4, 6062-6071, 2016. DOI:10.1021/Acssuschemeng.6b01394 |
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Lozano Rodriguez P., Bernal Palazón J.M., Gomez Garcia C., Garcia-Verdugo E., Luis S.V. Active Biopolymers In Green Non-Conventional Media: A Sustainable Tool For Developing Clean Chemical Processes. A Feature Article. Chemical Communications, 51, 17361-17374, 2015. DOI:10.1039/C5CC07600E |
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Julian Restrepo, Pedro Lozano, M. Isabel Burguete, Eduardo García-Verdugo, Santiago V. Luis, Gold nanoparticles immobilized onto supported ionic liquid-likephases for microwave phenylethanol oxidation in water. . Catalysis Today, 255, 97–101, 2015. DOI:10.1016/j.cattod.2014.12.023 |
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Pedro Lozano, Juana M. Bernal, Celia Gómez, Eduardo García-Verdugo,M. Isabel Burguete, Gregorio Sánchez, Michel Vaultier, Santiago V. Luis. Green bioprocesses in sponge-like ionic liquids. Catalysis Today, 255, 54–59, 2015. DOI:10.1016/j.cattod.2014.08.025 |
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Lozano Rodriguez P., Luis S.V., Garcia-Verdugo E., Fernandez Lafuente R. Green Catalysis-4th International Congress on Green Process Engineering (Gpe2014; Sevilla, Spain, April 7-10, 2014) Preface. Catalysis Today, . 255, 1-2, 2015. DOI: |
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Eduardo García-Verdugo, Belen Altava, M. Isabel Burguete, Pedro Lozano and S. V. Luisa. Ionic liquids and continuous flow processes: a good marriage to design sustainable processes. Green Chemistry, 17, 2693–2713, 2015. DOI:10.1039/c4gc02388a |
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Restrepo J.A., Porcar R., Lozano Rodriguez P., Burguete M.I., Garcia-Verdugo E., Luis S.V. Microwave-Assisted Selective Oxidation of 1-Phenyl-Ethanol in Water Catalyzed by Metal Nanoparticles Immobilized onto Supported Ionic Liquid-Like Phases. . Acs Catalysis, 5, 4743-4750, 2015. DOI:10.1021/acscatal.5b01129 |
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J. Luis Serrano, Jose Perez, Luis García, Gregorio Sanchez, Joaquín García, Pedro Lozano, Vidya Zende and Anant Kapdi. N-Heterocyclic-Carbene Complexes Readily Prepared from Di-µ-hydroxopalladacycles Catalyze the Suzuki Arylation of 9-Bromophenanthrene. Organometallics, 34, 522-533, 2015. DOI:10.1021/om501160n |
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Ardhapure A.V., Sanghvi Y., Kapdi A.R., Garcia Collado, Joaquin., Sanchez Gomez G., Lozano Rodriguez P., Serrano Martínez J.L. Pd-Imidate Complexes As Recyclable Catalysts For The Synthesis Of C5-Alkenylated Pyrimidine Nucleosides Via Heck Cross-Coupling Reaction. Rsc Advances, . 5, 24558-24563, 2015. DOI:10.1039/C5RA01461A |
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Pedro Lozano, Juana M. Bernal, Eduardo Garcia-Verdugo, Gregorio Sanchez-Gomez, Michel Vaultier, M. Isabel Burgueteb and Santiago V. Luis. Sponge-like ionic liquids: a new platform for green biocatalytic chemical processes. Green Chemistry, 17, 3706–3717, 2015. DOI:10.1039/c5gc00894h |
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D. F. Izquierdo, M. Yates, P. Lozano, M. I. Burguete, E. García-Verdugo, S.V. Luis. Macroporous polymers tailored as supports for large biomolecules: Ionic Liquids as porogenic solvents and as surface modifiers. Reactive & Functional Polymers, 2014. DOI:10.1016/j.reactfunctpolym.2014.09.026 |
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P. Lozano, J.M. Bernal, C. Gomez, E. Garcia-Verdugo, M.I. Burguete, G. Sanchez, M. Vaultier, S.V Luis. Green bioprocesses in sponge-like ionic liquids. Catal Today, 2014. DOI: 10.1016/j.cattod.2014.08.025. |
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P. Lozano, J. M. Bernal, A. Lajarin, D. Romera, E. Garcia-Verdugo, G. Sanchez-Gomez, M. Pucheault, M. Vaultier, M. I. Burguete, S. V. Luis. A Green approach for producing solvent-free anisyl acetate by enzyme catalyzed direct esterification in Sponge-Like Ionic Liquids under conventional and microwave heating. Curr. Green Chem. 1, 145-154, 2014. DOI: 10.2174/2213346101666131113201434 |
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A. Kapdi, V. Gayakhe, Y.S. Sanghvi, J. Garcia, P. Lozano, I. da Silva, I., J. Pérez and J.L. Serano. New water soluble Pd-imidate complexes as highly efficient catalysts for the synthesis of C5-arylated pyrimidine nucleosides. RSC Adv. 4, 17567–17572, 2014. DOI: DOI:10.1039/C4RA01326C |
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P. Lozano, B. Bernal, A.G. Jara, M.P. Belleville. Enzymatic membrane reactor for full saccharification of ionic liquid-pretreated cellulose. Bioresour. Technol. 151, 159-165, 2014. DOI:10.1016/j.biortech.2013.10.067 |
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D. F. Izquierdo, O. Barbosa, M. I. Burguete, P. Lozano, S. V. Luis, R. Fernandez-Lafuente and E. Garcia-Verdugo. Tuning lipase B from Candida antarctica C–C bond promiscuous activity by immobilization on polystyrene- divinylbenzene beads. RSC Advances, 4, 6219 – 6225, 2014. DOI:10.1039/C3RA47069E |
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B. Bernal, F.J. Chacón, A.G. Jara, M.P. Belleville, P. Lozano. A sustainable process for enzymatic saccharification of ionic liquidpretreated cellulosic materials. Green Processing & Synthesis. 2014 DOI: 10.1515/gps-2014-0055 |
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D. F Izquierdo, J. M. Bernal, M.I. Burguete, E. Garcia-Verdugo, P. Lozano and S. V. Luis. An efficient microwave-assisted enzymatic resolution of alcohols using a lipase immobilised on Supported Ionic Liquid-Like Phases (SILLPs). RSC Adv. 3, 13123-13126, 2013. DOI:10.1039/C3RA42467G |
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P. Lozano, J.M. Bernal, G. Sanchez, G. Lopez, M. Vaultier. How to produce biodiesel easily using a green biocatalytic approach in sponge-like ionic liquids. Energ. Environ. Sci., 6, 1328-1338, 2013. DOI:10.1039/C3EE24429F |
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P. Lozano, J. M. Bernal, A. Navarro. A clean enzymatic process for producing flavour esters by direct esterification in switchable ionic liquid/solid phases. Green Chem. 14, 3026-3033, 2013. DOI: 10.1039/C2GC36081K. Artículo destacado por Stephen K Ritter, Editor of Chemistry & Engineering News, en el artículo: Ionic Liquid Serves Up Natural Flavors, Chem. Eng. News, 91(4), 2013, 34-35. http://cen.acs.org/articles/91/i4/Ionic-Liquid-Serves-Natural-Flavors.html |
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P. Lozano, J. M. Bernal and A. Navarro. A clean enzymatic process for producing flavour esters by direct esterification in switchable ionic liquid/solid phases. Green Chemistry, 14, 3026-3033. 2012. DOI: 10.1039/C2GC35905G |
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P. Lozano, E. García-Verdugo, J.M. Bernal, D.F. Izquierdo, M.I. Burguete, G. Sánchez, S. V. Luis. Immobilized lipase onto structured supports containing covalently attached ionic liquids for continuous synthesis of biodiesel in scCO2. ChemSusChem, 5, 790-798. 2012. DOI: 10.1002/cssc.201100692 |
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P. Lozano, B. Bernal, I. Recio, M.P. Belleville. A cyclic process for full enzymatic saccharification of pretreated cellulose with full recovery and reuse of the ionic liquid 1-butyl-3-methylimidazolium chloride, Green Chem. 14, 2631-2637. 2012. DOI: 10.1039/c2gc35905g |
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J.M. Bernal, P. Lozano, E. García-Verdugo, M. I. Burguete, G. Sánchez-Gómez, G. López-Lopez, M. Pucheault, M. Vaultier, S. V. Luis. Supercritical Synthesis of Biodiesel: A review. Molecules, 17, 8696-8719. 2012. DOI: 10.3390/molecules17078696 |
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M. Sandoval, A. Cortes, C. Civera, J. Treviño, E. Ferreras, M. Vaultier, J. Berenguer, P. Lozano, and M. J. Hernáiz. Efficient and selective enzymatic synthesis of N-acelyl-lactosamine in ionic liquids: a rational explanation. RSC Advances, 2, 6306 – 6314. 2012. DOI: 10.1039/C2RA20618H |
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P. Lozano, B. Bernal, J.M. Bernal, M. Pucheault, M. Vaultier. Stabilizing immobilized cellulase by ILs for saccharification of cellulose solutions in [Bmim][Cl]. Green Chem. 13, 1406-1410. 2011. DOI: 10.1039/C1GC15294G |
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P. Lozano, E. Garcia-Verdugo, S.V. Luis, M. Pucheault, M. Vaultier. (Bio)catalytic continuous flow processes in scCO2 and/or ILs: Towards Sustainable (Bio)catalytic Synthetic Platforms. Curr. Org. Synth. 13, 4132-4135. 2011. DOI: 10.2174/157017911804586593 |
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P. Lozano, J.M. Bernal, M. Vaultier. Towards continuous sustainable processes for enzymatic synthesis of biodiesel in hydrophobic ILs/scCO2 biphasic systems. Fuel, 90, 3461-3467. 2011. DOI: 10.1016/j.fuel.2011.06.008 |
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Krishna Kishore Kukkadapu, Aziz Ouach, Pedro Lozano, Michel Vaultier, and Mathieu Pucheault. Achieving Chemo-, Regio-, and Stereoselectivity in Palladium-Catalyzed Reaction of γ-Borylated Allylic Acetates. Organic Letters, 13, 4132–4135. 2011. DOI: 10.1021/ol201661s |
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T. De Diego, A. Manjon, P. Lozano, M. Vaultier, J.L. Iborra. An efficient activity ionic liquid-enzyme system for biodiesel production. Green Chemistry, 13, 444-451. 2011. DOI: 10.1039/c0gc00230e |
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T. De Diego, A. Manjon, P. Lozano, J.L. Iborra. A recyclable enzymatic biodiesel production process in ionic liquids. Bioresource Technology, 102, 6336–6339. 2011. DOI: 10.1016/j.biortech.2011.02.071 |
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P. Lozano, E. Garcia-Verdugo, N. Karbass, K. Montague, T De Diego, M.I. Burguete, S.V. Luis. Supported ionic liquid-like phases (SILLPs) for enzymatic processes: Continuous KR and DKR in SILLP-scCO2 systems. Green Chem. 12, 1803-1810. 2010. DOI: 10.1039/C0GC00076K |
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P. Lozano. Enzymes in neoteric solvents: From one-phase to multiphase systems. Green Chem. 12, 555–569. 2010. DOI: 10.1039/B919088K |
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P. Lozano, J. M. Bernal, R. Piamtongkam, D. Fetzer, M. Vaultier. One-phase ionic liquid reaction medium for biocatalytic production of biodiesel. ChemSusChem, 3, 1359-1363. 2010. DOI: 10.1002/cssc.201000244 |
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P. Lozano, T. De Diego, J. L. Iborra. Enzymatic catalysis. In Handbook of Green Chemistry (Ed. P. Anastas), Vol. 4: Supercritical Solvents, (Ed. W. Leitner and P. G. Jessop), pp. 281-302. Wiley. ISBN: 978-3-527-32592-4. 2010. DOI: 10.1002/9783527628698.hgc040 |
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P. Lozano, T. De Diego, C. Mira, K. Montague, M. Vaultier. Long term continuous green chemoenzymatic DKR of rac-1-phenylethanol using ILs and scCO2. Green Chem. 11, 538-542. 2009 |
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P. Lozano, T. De Diego and J. L. Iborra. Biocatalytic processes using ionic liquids and supercritical carbon dioxide. In Handbook of Green Chemistry (Ed. Series P. Anastas), Vol. 3: Biocatalysis, (Ed. Vol. R. H. Crabtree). pp. 51-73. Wiley. ISBN: 978-3-527-32496-5. 2009. |
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T. De Diego, P. Lozano, M. A. Abad, K. Steffensky, M. Vaultier and J. L. Iborra. On the nature of ionic liquids and their effects on lipases that catalyze ester synthesis. Journal of Biotechnology, 140, 234-241, 2009 |
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T. De Diego, M. Vaultier and J. L. Iborra. Dynamic Kinetic Resolution of Sec-Alcohols in Ionic Liquids/Supercritical Carbon Dioxide Biphasic Systems. International Journal Of Chemical Reactors Engineering, 7, Article 79. Pp 1-13. 2009. DOI: 10.2202/1542-6580.2106. |
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P. Lozano, R. Piamtongkam, K. Kohns, T. De Diego, M. Vaultier, J.L. Iborra. Ionic liquids improve citronellyl ester synthesis catalyzed by immobilized C. antarctica lipase B in solvent-free media. Green Chem. 9, 780-784. 2007 |
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P. Lozano, E. Garcia-Verdugo, R. Piamtongkam, N. Karbass, T. De Diego, M.I. Burgete, S.V. Luis, J.L. Iborra. Bioreactors based on monolith-supported ionic liquid phase for enzyme catalysis in supercritical carbon dioxide. Adv. Synth. Catal. 349, 1077-1084. 2007 |
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P. Lozano, T. De Diego, T. Saüer, M. Vaultier, S. Gmouh and J. L. Iborra. On the importance of the supporting material for activity of immobilized Candida antarctica lipase B in ionic liquid/hexane and ionic liquid/supercritical carbon dioxide biphasic media. Journal of Supercritical Fluids, 40, 93 – 100. 2007 |
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P. Lozano, T. De Diego and J. L. Iborra. Enzymatic catalysis in ionic liquids and supercritical carbon dioxide biphasic systems. Chemistry Today – Chimica Oggi, 25, 16 – 19. 2007 |
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P. Lozano, T. De Diego, S. Gmouh , M. Vaultier and J. L. Iborra. A continuous reactor for the (chemo)enzymatic dynamic kinetic resolution of rac-1-phenylethanol in ionic liquid/supercritical carbon dioxide biphasic system. International Journal of Chemical Reactor Engineering, 5, Nº A53 (12 pag) 2007 |
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P. Lozano, T. De Diego, M. Larnicol, M. Vaultier and J. L. Iborra. Chemoenzypmatic dynamic kinetic resolution of rac-1-phenylethanol in ionic liquids and ionic liquids/supercritical carbon dioxide systems. Biotechnology Letters, 28, 1559 – 1565. 2006 |
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T. De Diego, P. Lozano, S. Gmöuh, M. Vaultier and J. L. Iborra. Understanding Structure-Stability Relationship of Candida antartica lipase B in ionic liquids. Biomacromolecules, 6, 1457 – 1464. 2005 |
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M. Mori, R. Gómez-García, M.P. Belleville, D. Paolucci-Jeanjean, J. Sánchez, P. Lozano, M. Vaultier and G.M. Rios. A new way to conduct enzymatic synthesis in an active membrane using ionic liquids as catalyst support. Catalysis Today, 104, 313-317. 2005 |
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P. Lozano, T. De Diego, S. Gmöuh, M. Vaultier and J. L. Iborra. Dynamic structure-function relationships in enzymes stabilization by ionic liquids. Biocatalysis & Biotransformations, 23 (3-4), 169-176. 2005 |
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M. Noel, P. Lozano and D. Combes. Polyhydric alcohol protective effect on Rhizomucor miehei lipase deactivation enhanced by pressure and temperature treatment. Bioprocess and Biosystems Engineering, 27 (6), 375-380. 2005 |
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P. Lozano, G. Víllora, D. Gómez, A.B. Gayo, J.A. Sánchez-Conesa, M. Rubio. Membrane reactor with immobilized CALB for ester synthesis in scCO2. J. Supercrit. Fluids, 29, 121-128. 2004. |
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P. Lozano, T. De Diego, S. Gmöuh, M. Vaultier, J.L. Iborra. Synthesis of glycidyl esters catalyzed by lipases in IL and scCO2. J. Mol. Catal. A: Chem. 214, 113-119. 2004. |
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P. Lozano, T. De Diego, S. Gmöuh, M. Vaultier, J.L. Iborra. Criteria to design green enzymatic processes in IL and scCO2 systems. Biotechnol. Progr. 20, 661 – 669. 2004. |
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M. Nöel, P. Lozano, M. Vaultier and J. L. Iborra. Kinetic resolution of rac-2-pentanol catalyzed by Candida antarctica lipase B in the ionic liquid, 1-butyl-3-methylimidazolonium bis[(trifluoromethyl)sulfonyl]aminde. Biotechnology Letters, 26, 301 – 306. 2004 |
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T. De Diego, P. Lozano, S. Gmöuh, M. Vaultier and J. L. Iborra. Fluorescence and CD spectroscopic analysis of the -chymotrypsin stabilization by the ionic liquid, 1-ethyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]amide. Biotechnology & Bioengineering, 88 (7), 916 – 924. 2004 |
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P. Lozano, T. De Diego, D. Carrié, M. Vaultier, J.L. Iborra. Enzymatic ester synthesis in ionic liquids. J. Mol. Catal. B: Enzym. 21, 9-13. 2003. |
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P. Lozano, T. De Diego, D. Carrié, M. Vaultier, J.L. Iborra. Lipase catalysis in ionic liquids and supercritical carbon dioxide at 150ºC. Biotechnol. Progr. 19, 380 - 382. 2003. |
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P. Lozano, M. Daz, T. De Diego and J. L. Iborra. Ester synthesis from trimethylammonium alcohols in dry organic media catalyzed by Candida antarctica lipase B. Biotechnology and Bioengineering, 82, 352 – 358. 2003 |
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P. Lozano, T. De Diego, D. Carrié, Michel Vaultier,J.L. Iborra. Continuous green biocatalytic processes using ionic liquids and supercritical carbon dioxide. Chem. Commun., 692-693. Artículo destacado por Philip Ball, Editor of Nature, en el articulo “Enzymes find pastures greener”, Nature Science Update. April 23, 2002. http://www.nature.com/nsu/020415/020415-3.html |
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P. Lozano, A.B. Pérez-Marín, T. De Diego, D. Gómez, D. Paolucci-Jeanjean, M.P. Belleville, G.M. Rios and J. L. Iborra. Active membranes coated with immobilized Candida antarctica lipase B: Preparation and application for continuous butyl butyrate synthesis in organic media. Journal of Membrane Science. 201, 55 – 64. 2002 |
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S. Chulalaksananukul, W. Chulalaksananukul, P. Lozano and D. Combes. Long-term continuous synthesis of geranyl acetate in a column reactor with an immobilized lipase. Thai Journal of Agricultural Science. 35 (1), 9 – 16, 2002 |
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P. Lozano, T. de Diego, D. Carrié, Michel Vaultier, J.L. Iborra. Over-stabilization of Candida antarctica lipase B by ionic liquids in ester síntesis. Biotechnol. Lett. 23, 1529-1533. 2001. |
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P. Lozano, T. de Diego, J.P. Guegan, M. Vaultier, J.L. Iborra. Stabilization of alpha-chymotrypsin by ionic liquids in transesterification reactions. Biotechnol. Bioeng. 75, 563-569. 2001. |
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M.P. Belleville, P. Lozano, J. L. Iborra and G.M. Rios. Prepararion of hybrid membranes for enzymatic reaction. Separation and Purification Technology, 25 (1), 229-223, 2001 |
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V. Levitsky, P. Lozano and J. L. Iborra. Designing enzymatic kyotorphin synthesis in organic media with low water content. Enzyme and Microbial Technology, 26, 608 – 613, 2000 |
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P. Lozano, D. Delgado, D. Gómez, M. Rubio and J.L. Iborra. A non destructive method to determine the safranal content in saffron (Crocus sativus L.) using supercritical carbon dioxide extraction combined with HPLC and GC. Journal of Biochemical and Biophysical Methods, 43, 367 – 378, 2000 |
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P. Lozano, T. De Diego, M. P. Belleville, G. M. Rios and J. L. Iborra. A dynamic membrane reactor with immobilized -chymotrypsin for continuous kyotorphin synthesis in organic media. Biotechnology Letters. 22, 771 – 775, 2000 |
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P. Lozano, M.R. Castellar, M.J. Simáncas and J. L. Iborra. Quantitative high-performance liquid chromatographic method to analyse commercial saffron (Crocus sativus L.) products. Journal of Chromatography A, 830, 477 – 483, 1999 |
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V. Levitsky, P. Lozano and J. L. Iborra. Glycosylated -chymotrypsin as a catalyst for kyotorphin synthesis in water-organic media. Biotechnology Letters, 21, 595 – 599, 1999 |
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V. Levitsky, P. Lozano and J. L. Iborra. Kinetic analysis of deactivation of immobilized -chymotrypsin by water-miscible organic solvent in kyotorphin synthesis. Biotechnology and Bioengineering, 65,170 – 175, 1999 |
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M. T. Pretel, P. Lozano, F. Riquelme and F. Romojaro. Pectic enzymes in fresh fruit processsing: Optimization of the peeling of oranges. Process Biochemistry, 32 (1), 43 - 49. 1997 |
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P. Lozano, T. de Diego and J.L. Iborra. Dynamic structure/function relationships in the -chymotrypsin deactivaton process by heat and pH. European Journal of Biochemistry, 248, 80 – 85, 1997 |
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P. Lozano, T. de Diego and J.L. Iborra. Hydrophobicity and water activity relatioships of water-miscible aprotic solvents on kyotorphin synthesis catalyzed by -chymotrypsin. Biotechnology Letters. 19(10), 1005 – 1009, 1997 |
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P. Lozano, A. Avellaneda and J.L. Iborra. Peptide synthesis by papain in alkali halide media. Biocatalysis and Biotransformations, 13, 255 – 269, 1996 |
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P. Lozano, T. de Diego and J.L. Iborra. Influence of water miscible aprotic solvents on -chymotrypsin stability. Biotechnology Progress. 12, 488 – 493, 1996 |
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P. Lozano, A. Avellaneda, R. Pascual and J.L. Iborra. Stability of immobilized -chymotrypsin in supercritical carbon dioxide. Biotechnology Letters. 18 (11), 1351 – 1356, 1996 |
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P. Lozano, T. Diego and J.L. Iborra. Effect of water-miscible aprotic solvents on kyotorphin synthesis catalyzed by immobilized -chymotrypsin. Biotechnology Letters. 17 (6), 603 – 608, 1995 |
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A. Manjón, J.L. Iborra, P. Lozano and M. Cánovas. A practical experiment on enzyme immobilization and characterization of the immobilized derivatives. Biochemical Education. 23 (4), 213 – 216, 1995 |
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P. Lozano, J.L. Iborra and A.J.P. Rocha. Cryo-enzymatic synthesis of kyotorphin in saline environments. Biochemistry and Molecular Biology International, 33 (1), : 91 - 97. 1994. |
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P. Lozano, D. Combes and J.L. Iborra. Effect of polyols on -chymotrypsin thermostability: A mechanistic analysis of the enzyme stabilization. Journal of Biotechnology, 35, : 9 - 18. 1994. |
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P. Lozano, D. Combes and J.L. Iborra. Effect of polyols on -chymotrypsin thermostability: A mechanistic analysis of the enzyme stabilization. Journal of Biotechnology, 35, : 9 - 18. 1994. |
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J.L. Iborra, A. Manjón, M. Cánovas, P. Lozano and C. Martínez. Continuous limonin degradation by immobilized Rhodococcus fascians cells in K-carrageenan. Applied Microbiology and Biotechnology. 41, 487 - 493. 1994 |
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P. Lozano, D. Combes and J.L. Iborra. Food protein nutrient improvement by protease at reduced water activity. Journal of Food Science. 59 (4), 876 – 880, 1994 |
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P. Lozano, J. Cano, J.L. Iborra and A. Manjón. Glycylglycylphenylalaninamide synthesis catalyzed by papain in a medium containing polyols. 18, 67 - 74. 1993 |
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P. Lozano, J. Cano, J.L. Iborra and A. Manjón. Influence of polyhydroxilic cosolvents on papain thermostability. Enzyme and Microbial Technology. 15, 868 – 873, 1993 |
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P. Lozano and D. Combes. Effect of alkali halides on -chymotrypsin activity in the plastein reaction. Journal of the Science of Food and Agricultural. 62, 245 – 252, 1993. |
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P. Lozano, D. Combes, J.L Iborra and A. Manjón. Synthesis of L-tyrosine glyceryl ester catalyzed by -chymotrypsin in water miscible organic solvents: a possible sun-tan accelerator product. Biotechnology Letters, 15 (12), 1223 - 1228. 1993. |
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P. Lozano and D. Combes. chymotrypsin in plastein synthesis: Influence of hydroxylated additives on enzyme activity. Applied Biochemistry and Biotechnology, 12, 51 - 65. 1992. |
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D. Combes and P. Lozano. -chymotrypsin in plastein synthesis: Influence of water activity. Annals of the New York Academy of Sciences, 672, 409 - 414. 1992. |
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P. Lozano, J.L. Iborra, A. Manjón and D. Combes. One step synthesis of Gly-Gly-PheNH2 from N-unprotected amino acid derivatives by papain in one-phase liquid media. Biotechnology Letters, 14, 933 - 936. 1992. |
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P. Lozano and D. Combes. -chymotrypsin in plastein synthesis: Influence of the substrate concentration on enzyme activity. Biotechnology and Applied Biochemistry, 14, 212 – 221, 1991. |
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P. Lozano, A. Manjón, J.L. Iborra, M. Cánovas and F. Romojaro. Kinetic and operational study of a cross-flow reactor with immobilized pectolytic enzymes. Enzyme and Microbial Technology, 12, 499 - 505. 1990. |
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P. Lozano, A. Manjón, J.L. Iborra and M.D. Gálvez. Characteristics of the immobilized pectin lyase activity from a commercial pectolytic enzyme preparation. Acta Biotechnologica, 10 (6), 519 - 527. 1990. |
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P. Lozano, A. Manjón, F. Romojaro and J.L. Iborra. Properties of pectolytic enzymes covalently bound to nylon for apricot juice clarification. Process Biochemistry. 23 (3), 75 - 78. 1988 |
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P. Lozano, A. Manjón, F. Romojaro, M. Cánovas and J.L. Iborra. A cross-flow reactor with immobilized pectolytic enzymes for juice clarification. Biotechnology Letters, 9 (12), 875 - 880. 1987. |
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Professional address |
Department of Biochemistry and Molecular Biology “B” and Immunology.
Faculty of Chemistry. University of Murcia.
Campus de Espinardo. P.O. Box 4021. E-30100- Murcia. Spain.
Phone: +34.868.88.7392. Fax: +34.868.88.41.48
Email: plozanor@um.es |
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