Dr. José Ruiz

Department of Inorganic Chemistry - Murcia University

 

 

Spanish version spain

Wellcome to the website of José Ruiz, Professor in Inorganic Chemistry of the Murcia University

Member of the Working Group #4 of COST Action CM1105 (“Functional metal complexes that bind to biomolecules”)

Present position
José Ruiz is Professor in Inorganic Chemistry
Faculty: Chemistry
Department: Inorganic Chemistry. Metallopharmaceutical Group.
Postal address: Departamento de Química Inorgánica, Universidad de Murcia, Campus Universitario de Espinardo, 30071 – Espinardo - Murcia. Spain
Phone: +34 868 88 74 55 / Fax: +34 868 88 41 48
e-mail: jruiz@um.es

Postdoctoral experience
Center: Department of Chemistry. University of Sheffield. U.K.
Date: 1984 / 86


Last publications

Portada en:

JOURNAL OF MEDICINAL CHEMISTRY

Volume 67 | Number 10 | 23 May 2024

 

Novel Re(I) Complexes as Potential Selective Theranostic Agents in Cancer Cells and In Vivo in Caenorhabditis elegans Tumoral Strains. Alicia Marco; Pezhman Ashoo; Samanta Hernández-García; Pedro Martínez-Rodríguez; Natalia Cutillas; Annette Vollrath; Dustin Jordan; Christoph Janiak; Fernando Gandía-Herrero; José Ruiz. Journal of Medicinal Chemistry. 67, 10, 7891–7910 (2024). DOI:10.1021/acs.jmedchem.3c01869

 

New Cyclometalated Ru(II) Polypyridyl Photosensitizers Trigger Oncosis in Cancer Cells by Inducing Damage of Cellular Membranes. Jakub Cervinka; Alba Hernández-García; Delia Bautista; Lenka Marková; Hana Kostrhunova; Jaroslav Malina; Jana Kasparkova; M. Dolores Santana; Viktor Brabec; Jose Ruiz. Inorganic Chemistry Frontiers (2024). DOI: 10.1039/d4qi00732h

 

Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells. Jana Kasparkova; Vojtech Novohradsky; José Ruiz; Viktor Brabec. Chemico-Biological Interactions. 392:110921 (2024). DOI:10.1016/j.cbi.2024.110921

 

Portada en:

INORGANIC CHEMISTRY

Volume 63 | Number 14 | 8 April 2024

 

Photoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1,2,3-triazole Chelators for Cancer Treatment. Francisco J. Ballester; Alba Hernández-García; M. Dolores Santana; Delia Bautista; Pezhman Ashoo; Enrique Ortega-Forte; Giampaolo Barone; José Ruiz. Inorganic Chemistry. 63, 14, 6202–6216 (2024). DOI: 10.1021/acs.inorgchem.3c04432

 

Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis. Jana Kasparkova, Alba Hernández-García, Hana Kostrhunova, Marta Goicuría, Vojtec Novohradsky, Delia Bautista, Lenka Markova, María Dolores Santana, Viktor Brabec and José Ruiz. J. Med. Chem. 67, 1, 691–708 (2024). DOI:10.1021/acs.jmedchem.3c01978

 

A near-infrared light-activatable Ru(<scp>ii</scp>)-coumarin photosensitizer active under hypoxic conditions. Enrique Ortega-Forte, Anna Rovira, Marta López-Corrales, Alba Hernández-García, Francisco José Ballester, Eduardo Izquierdo-García, Mireia Jordà-Redondo, Manel Bosch, Santi Nonell, María Dolores Santana, José Ruiz, Vicente Marchán and Gilles Gasser. Chem. Sci. 14, 7170-7184 (2023). DOI: 10.1039/D3SC01844J

 

Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria. Alicia Marco, Gloria Vigueras, Natalia Busto, Natalia Cutillas, Delia Bautista and José Ruiz. Dalton Trans. 52, 13482-13486 (2023). DOI:10.1039/D3DT01678A

 

Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells. Vojtech Novohradsky, Alicia Marco, Lenka Markova, Natalia Cutillas, José Ruiz and Viktor Brabec. J. Med. Chem. 66, 14, 9766–9783 (2023). DOI: 10.1021/acs.jmedchem.3c00586

 

Exploring Structure–Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates. Anna Rovira, Martí i Franquès, Enrique Ortega-Forte, Cormac Hally, Mireia Jordà-Redondo, Diego Abad-Montero, Gloria Vigueras, Jesús I. Martínez, Manel Bosch, Santi Nonell, José Ruiz and Vicente Marchán. J. Med. Chem. 66, 12, 7849–7867 (2023). DOI: 10.1021/acs.jmedchem.3c00189

 

Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis. Alba Hernández-García, Lenka Marková, María Dolores Santana, Jitka Prachařová, Delia Bautista, Hana Kostrhunová, Vojtěch Novohradský, Viktor Brabec, José Ruiz and Jana Kašpárková. Inorg. Chem. 62, 16, 6474–6487 (2023). DOI: 10.1021/acs.inorgchem.3c00501

 

Newly synthesized benzothiazolyl-1,2,3-triazole derivatives: Intramolecular charge transfer tuning, solvatofluorochromism and antiproliferative properties. F. J. Ballester; E. Ortega-Forte; D. Bautista; M. D. Santana; G. Barone; J. Ruiz. Dyes and Pigments, 209-A, 110905 (2023). DOI: 10.1016/j.dyepig.2022.110905

 

 

 

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